Tsutsui Hidemitsu, Tamura Atsumi, Ito Junko, Ohara Ryoji, Hoshi Masae, Kubota Mitsuhiro, Yano Yukiko, Ikeda Norihiko
Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023 Japan.
Indian J Surg Oncol. 2022 Mar;13(1):184-190. doi: 10.1007/s13193-021-01466-7. Epub 2021 Oct 27.
Thyroid cancer invading the trachea can be asymptomatic, but when tumour invasion reaches the mucosal surface, it causes bloody sputum and dyspnoea. The treatment plan for thyroid cancer is determined based on the site, depth, and extent of the invasion. Different from tumours arising from the tracheal mucosa, in thyroid cancer, invasion begins outside the airway and progresses toward the lumen, making it difficult to accurately diagnose the extent of the invasion even with bronchoscopy. Therefore, surgeons must determine the range of resection during surgery. Invasion reaching the tracheal mucosa requires full-thickness resection and is performed using tracheal window resection combined with tracheocutaneous fistula or tracheal sleeve resection followed by end-to-end anastomosis. The airway is safely secured with window resection, but closing the tracheal stoma often requires multi-stage reconstruction. Sleeve resection is an oncologically appropriate surgical method that can be completed in one stage, although there is a risk of serious complications associated with anastomotic dehiscence. Since well-differentiated thyroid cancer progresses slowly, some degree of survival can be expected even with incomplete resection. However, when shaving is performed for tumours with deep invasion that reaches the tracheal mucosa, the residual tumour tissue continues to grow steadily and eventually leads to airway stenosis. Since reoperation for tracheal resection is difficult, radical full-thickness resection should be performed in the initial surgery. Although this surgical intervention is far more demanding for both patients and surgeons than shaving, the procedure eventually improves patient's prognosis and quality of life.
甲状腺癌侵犯气管时可能没有症状,但当肿瘤侵犯到黏膜表面时,会导致咯血和呼吸困难。甲状腺癌的治疗方案是根据侵犯的部位、深度和范围来确定的。与起源于气管黏膜的肿瘤不同,甲状腺癌的侵犯始于气道外并向管腔发展,即使使用支气管镜检查也难以准确诊断侵犯的范围。因此,外科医生必须在手术中确定切除范围。侵犯到气管黏膜需要进行全层切除,可采用气管开窗切除术联合气管皮肤造瘘术或气管袖状切除术,然后进行端端吻合。通过开窗切除术可安全保障气道,但关闭气管造口通常需要多阶段重建。袖状切除术是一种在肿瘤学上合适的手术方法,虽然存在吻合口裂开相关的严重并发症风险,但可以一期完成。由于分化良好的甲状腺癌进展缓慢,即使不完全切除也有望获得一定程度的生存期。然而,对于侵犯到气管黏膜的深部肿瘤进行刮除术时,残留的肿瘤组织会持续稳定生长,最终导致气道狭窄。由于气管切除的再次手术困难,初次手术时应进行根治性全层切除。虽然这种手术干预对患者和外科医生的要求远高于刮除术,但该手术最终会改善患者的预后和生活质量。