Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Neural Plast. 2020 Oct 8;2020:8891458. doi: 10.1155/2020/8891458. eCollection 2020.
Freezing of gait (FOG) is a disabling gait disorder influencing patients with Parkinson's disease (PD). Accumulating evidence suggests that FOG is related to the functional alterations within brain networks. We investigated the changes in brain resting-state functional connectivity (FC) in patients with PD with FOG (FOG+) and without FOG (FOG-).
Resting-state functional magnetic resonance imaging (RS-fMRI) data were collected from 55 PD patients (25 FOG+ and 30 FOG-) and 26 matched healthy controls (HC). Differences in intranetwork connectivity between FOG+, FOG-, and HC individuals were explored using independent component analysis (ICA).
Seven resting-state networks (RSNs) with abnormalities, including motor, executive, and cognitive-related networks, were found in PD patients compared to HC. Compared to FOG- patients, FOG+ patients had increased FC in advanced cognitive and attention-related networks. In addition, the FC values of the auditory network and default mode network were positively correlated with the Gait and Falls Questionnaire (GFQ) and Freezing of Gait Questionnaire (FOGQ) scores in FOG+ patients.
Our findings suggest that the neural basis of PD is associated with impairments of multiple functional networks. Notably, alterations of advanced cognitive and attention-related networks rather than motor networks may be related to the mechanism of FOG.
冻结步态（FOG）是一种使人致残的步态障碍，影响帕金森病（PD）患者。越来越多的证据表明，FOG 与大脑网络内的功能改变有关。我们研究了伴有 FOG（FOG+）和不伴有 FOG（FOG-）的 PD 患者的大脑静息态功能连接（FC）的变化。
从 55 名 PD 患者（25 名 FOG+和 30 名 FOG-）和 26 名匹配的健康对照者（HC）中收集静息态功能磁共振成像（RS-fMRI）数据。使用独立成分分析（ICA）探讨 FOG+、FOG-和 HC 个体之间的内在网络连接的差异。
与 HC 相比，PD 患者存在 7 个异常的静息态网络（RSN），包括运动、执行和认知相关网络。与 FOG-患者相比，FOG+患者在高级认知和注意力相关网络中存在 FC 增加。此外，听觉网络和默认模式网络的 FC 值与 FOG+患者的步态和跌倒问卷（GFQ）和冻结步态问卷（FOGQ）评分呈正相关。
我们的研究结果表明，PD 的神经基础与多个功能网络的损伤有关。值得注意的是，高级认知和注意力相关网络的改变而不是运动网络的改变可能与 FOG 的机制有关。
