产肠毒素大肠杆菌和霍乱弧菌O1致病决定因素的进化起源
Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1.
作者信息
Yamamoto T, Gojobori T, Yokota T
出版信息
J Bacteriol. 1987 Mar;169(3):1352-7. doi: 10.1128/jb.169.3.1352-1357.1987.
Abstract
Three families of the evolutionarily related pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1, a family of cholera enterotoxin (CT) and heat-labile enterotoxin (LT) including CT, LTh, and LTp, a family of heat-stable enterotoxin I (STI) including STIa and STIb, and a family of K88 enteroadhesion fimbriae including K88ab, K88ac, and K88ad were analyzed for synonymous (silent) nucleotide substitutions by using the gene nucleotide sequences of earlier reports and the LTp gene nucleotide sequence presented in this paper. The data suggested that the divergences between LT and CT and between STIa and STIb occurred in the remote past, whereas those between LTh and LTp and between members of the K88 family occurred very recently. We concluded that the LT gene is a foreign gene that has been acquired by E. coli to form an enteropathogen. This provides evolutionary evidence of species-to-species transfer of pathogenic determinants in procaryotes.
摘要
对产肠毒素大肠杆菌和霍乱弧菌O1中进化相关致病决定因素的三个家族进行了分析，这三个家族分别是：一个由霍乱肠毒素（CT）和不耐热肠毒素（LT，包括CT、LTh和LTp）组成的家族，一个由耐热肠毒素I（STI，包括STIa和STIb）组成的家族，以及一个由K88肠黏附菌毛（包括K88ab、K88ac和K88ad）组成的家族。利用早期报告中的基因核苷酸序列和本文给出的LTp基因核苷酸序列，分析了同义（沉默）核苷酸替换情况。数据表明，LT与CT之间以及STIa与STIb之间的差异发生在遥远的过去，而LTh与LTp之间以及K88家族成员之间的差异则是最近才出现的。我们得出结论，LT基因是大肠杆菌获得的一个外源基因，使其成为一种肠道病原体。这为原核生物中致病决定因素在物种间转移提供了进化证据。
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