Wargasetia Teresa Liliana, Ratnawati Hana, Widodo Nashi
Faculty of Medicine, Universitas Kristen Maranatha (Maranatha Christian University), Bandung, Indonesia.
Department of Biology, Faculty of Mathematics and Natural Sciences, The University of Brawijaya, Indonesia.
Bioinform Biol Insights. 2022 Apr 17;16:11779322221091740. doi: 10.1177/11779322221091740. eCollection 2022.
Cancer is a major health problem worldwide and the leading cause of death in many countries. It remains challenging to find anticancer treatments that work efficiently for varying types of cancer cells. Several studies revealed that nuclear factor kappa B (NF-κB) is a family of dimeric transcription factors that induce tumor promotion, progression, and therapeutic resistance, providing evidence that NF-kB may be a promising target for cancer drugs. Some research has found that sea cucumber biocompounds have anticancer properties, but further research is essential to confirm anticancer targets. This manuscript discusses the mechanisms of anticancer targeting the NF-κB signaling pathway induced by sea cucumber-derived compounds. Additional database analysis showed the protein targeted by the compounds involved in several pathways related to the NF-κB network. Moreover, SwissADME predicted druglikeliness properties of the active compounds of sea cucumber. The discussion is expected to provide new insight into the promising potential of these marine natural products for the treatment of many different types of cancers.
癌症是全球主要的健康问题，也是许多国家的主要死因。找到对不同类型癌细胞都有效的抗癌治疗方法仍然具有挑战性。多项研究表明，核因子κB（NF-κB）是一类二聚体转录因子家族，可诱导肿瘤促进、进展和治疗抗性，这为NF-κB可能成为癌症药物的一个有前景的靶点提供了证据。一些研究发现海参生物活性成分具有抗癌特性，但进一步研究对于确认抗癌靶点至关重要。本文讨论了海参衍生化合物诱导的针对NF-κB信号通路的抗癌机制。额外的数据库分析表明，这些化合物靶向的蛋白质涉及与NF-κB网络相关的多个通路。此外，SwissADME预测了海参活性化合物的类药性质。预期该讨论将为这些海洋天然产物在治疗多种不同类型癌症方面的潜在前景提供新的见解。
