Department of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran.
Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran.
Asian Pac J Cancer Prev. 2024 Oct 1;25(10):3717-3723. doi: 10.31557/APJCP.2024.25.10.3717.
Hepatocellular carcinoma (HCC) is a significant type of liver cancer. In spite of many treatment approaches, its treatment is still associated with challenges. Therefore, new approaches with minimal side effects are necessary for its treatment. Sea cucumbers are marine animals that have many biologically active compounds. They are rich in useful compounds and have high nutritional value. It has been reported to have many pharmacological effects, including anticancer. This research was designed to investigate the effects of Holothuria lessoni (H. lessoni) sea cucumber toxicity in HCC model rats.
Cancer was induced in rats using diethyl nitrosamine (200 mg/kg DEN/single dose) + 2-acetylaminofluorene (2-AAF/ dietary/ 0.02% w/w for two weeks). After 15 weeks, hepatocytes and mitochondria were isolated to evaluate toxicity tests.
The results of the study showed that H. lessoni (62.5, 125, and 250 µg/ml) were able to cause toxicity only in cancerous mitochondria by increasing the level of free radicals, disrupting the permeability of the mitochondrial membrane, and initiating cell death signaling (p<0.05).
It was suggested that H. lessoni sea cucumber may be beneficial in the treatment of HCC along with selected drugs. However, more studies are needed.
肝细胞癌（HCC）是一种重要的肝癌类型。尽管有许多治疗方法，但它的治疗仍然存在挑战。因此，需要新的、副作用最小的方法来治疗它。海参是一种海洋动物，含有许多具有生物活性的化合物。它们富含有用的化合物，具有很高的营养价值。据报道，海参具有多种药理作用，包括抗癌作用。本研究旨在探讨糙海参（H. lessoni）海参毒性对 HCC 模型大鼠的影响。
采用二乙基亚硝胺（200mg/kg DEN/单次剂量）+ 2-乙酰氨基芴（2-AAF/饮食/2 周，0.02% w/w）诱导大鼠癌症。15 周后，分离肝细胞和线粒体以评估毒性试验。
研究结果表明，糙海参（62.5、125 和 250μg/ml）仅能通过增加自由基水平、破坏线粒体膜的通透性和启动细胞死亡信号来引起癌变线粒体的毒性（p<0.05）。
建议糙海参可能有益于与选定药物联合治疗 HCC。但是，还需要更多的研究。
