海参来源化合物诱导癌细胞死亡的机制。
Mechanisms of cancer cell killing by sea cucumber-derived compounds.
机构信息
Faculty of Medicine, Universitas Kristen Maranatha (Maranatha Christian University), Jl. Prof. Drg. Suria Sumantri MPH No. 65, Bandung, 40164, Indonesia.
Biology Department, Faculty of Mathematics and Natural Sciences, The University of Brawijaya, Jl. Veteran, Malang, 65145, Indonesia.
出版信息
Invest New Drugs. 2017 Dec;35(6):820-826. doi: 10.1007/s10637-017-0505-5. Epub 2017 Sep 18.
Abstract
The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.
摘要
癌症治疗的目的是特异性地消灭肿瘤细胞，同时对正常组织造成最小的损伤和最小的副作用。因此，使用毒性低的天然物质是一个很好的选择。海参是许多具有潜在药用价值的海洋动物之一，含有有价值的营养物质和药用特性。海参的药用价值归因于存在具有有前途的生物和药理特性的生物活性物质，包括细胞毒性活性、诱导细胞凋亡、细胞周期停滞、抑制肿瘤生长、抗转移和抗血管生成特性以及抑制耐药性。本综述讨论了海参衍生化合物诱导癌细胞死亡的机制，以期探索这些海洋天然产物在癌症治疗中的潜在用途。
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