Bagwe Pritam V, Bagwe Priyal V, Ponugoti Sai Srinivas, Joshi Shreerang V
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, Maharashtra 400019 India.
Vaccine Nanotechnology Laboratory, Center for Drug Delivery and Research, College of Pharmacy, Mercer University, Atlanta, GA 30341 USA.
Int J Pept Res Ther. 2022;28(3):94. doi: 10.1007/s10989-022-10397-y. Epub 2022 Apr 19.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been prevalent in the humans since 2019 and has given rise to a pandemic situation. With the discovery and ongoing use of drugs and vaccines against SARS-CoV-2, there is still no surety of its complete suppression of this disease or if there is a need for additional booster doses. There is an urgent need for alternative treatment strategies against COVID-19. Peptides and peptidomimetics have several advantages as therapeutic agents because of their target selectivity, better interactions, and lower toxicity. Minor structural alterations to peptides can help prevent their fast metabolism and provide long-action. This comprehensive review provides an overview of different peptide-based vaccines and therapeutics against SARS-CoV-2. It discusses the design and mechanism of action of the peptide-based vaccines, peptide immunomodulators, anti-inflammatory agents, and peptides as entry inhibitors of SARS-CoV-2. Moreover, the mechanism of action, sequences and current clinical trial studies are also summarized. The review also discusses the future aspects of peptide-based vaccines and therapeutics for COVID-19.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）自2019年以来一直在人类中流行，并引发了大流行状况。随着针对SARS-CoV-2的药物和疫苗的发现及持续使用，仍无法确定其能否完全抑制这种疾病，或者是否需要额外的加强剂量。迫切需要针对COVID-19的替代治疗策略。肽和肽模拟物作为治疗剂具有几个优点，因为它们具有靶点选择性、更好的相互作用和更低的毒性。对肽进行微小的结构改变可以帮助防止其快速代谢并提供长效作用。这篇综述全面概述了针对SARS-CoV-2的不同基于肽的疫苗和疗法。它讨论了基于肽的疫苗、肽免疫调节剂、抗炎剂以及作为SARS-CoV-2进入抑制剂的肽的设计和作用机制。此外，还总结了其作用机制、序列和当前的临床试验研究。该综述还讨论了基于肽的COVID-19疫苗和疗法的未来发展方向。
