Department of Biochemistry, Government College for Women, Thiruvananthapuram, Kerala, India.
Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
J Infect Public Health. 2021 Aug;14(8):1106-1119. doi: 10.1016/j.jiph.2021.06.017. Epub 2021 Jul 3.
Recent advances in peptide research revolutionized therapeutic discoveries for various infectious diseases. In view of the ongoing threat of the COVID-19 pandemic, there is an urgent need to develop potential therapeutic options. Intense and accomplishing research is being carried out to develop broad-spectrum vaccines and treatment options for corona viruses, due to the risk of recurrent infection by the existing strains or pandemic outbreaks by new mutant strains. Developing a novel medicine is costly and time consuming, which increases the value of repurposing existing therapies. Since, SARS-CoV-2 shares significant genomic homology with SARS-CoV, we have summarized various peptides identified against SARS-CoV using in silico and molecular studies and also the peptides effective against SARS-CoV-2. Dissecting the molecular mechanisms underlying viral infection could yield fundamental insights in the discovery of new antiviral agents, targeting viral proteins or host factors. We postulate that these peptides can serve as effective components for therapeutic options against SARS-CoV-2, supporting clinical scientists globally in selectively identifying and testing the therapeutic and prophylactic agents for COVID-19 treatment. In addition, we also summarized the latest updates on peptide therapeutics against SARS-CoV-2.
近年来，肽研究的进展彻底改变了各种传染病的治疗发现。鉴于 COVID-19 大流行的持续威胁，迫切需要开发潜在的治疗选择。由于现有菌株反复感染或新突变株引发大流行的风险，正在进行激烈而有成效的研究，以开发广谱疫苗和治疗冠状病毒的方法。开发新药既昂贵又耗时，这增加了重新利用现有疗法的价值。由于 SARS-CoV-2 与 SARS-CoV 具有显著的基因组同源性，我们总结了使用计算机和分子研究针对 SARS-CoV 鉴定的各种肽，以及对 SARS-CoV-2 有效的肽。解析病毒感染的分子机制可以为发现新的抗病毒药物提供基础见解，针对病毒蛋白或宿主因子。我们假设这些肽可以作为治疗 SARS-CoV-2 的有效成分，支持全球临床科学家有针对性地识别和测试 COVID-19 治疗的治疗和预防药物。此外，我们还总结了针对 SARS-CoV-2 的肽治疗的最新进展。
