胸腺癌：综述

Alqaidy Doaa, Moran Cesar A

Department of Pathology and Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States.

Department of Pathology, MD Anderson Cancer Center, University of Texas, Houston, TX, United States.

Front Oncol. 2022 Apr 8;12:808019. doi: 10.3389/fonc.2022.808019. eCollection 2022.

The diagnosis of thymic carcinoma may pose significant problems not necessarily in the histopathological diagnosis but rather in assigning the thymus as specific origin. Often the tissue available for interpretation is obtained a mediastinocopic biopsy, which raises two different issues -minimal tissue and lack of specific features to make a carcinoma of thymic origin. In addition, if to that conundrum we add that there is no magic immunohistochemical stain that will unequivocally lead to the interpretation of thymic carcinoma, then we are left with a true clinical-radiological-pathological correlation. In this review, we will highlight some of those challenges that diagnostic surgical pathologists may encounter in the histopathological assessment of thymic carcinoma as well as in the staging of these tumors.

胸腺癌的诊断可能会带来重大问题，这不一定在于组织病理学诊断，而在于确定胸腺为特定起源。通常，用于解读的组织是通过纵隔镜活检获得的，这引发了两个不同的问题——组织量少以及缺乏明确特征来诊断胸腺起源的癌。此外，如果再加上没有一种神奇的免疫组化染色能明确诊断胸腺癌，那么我们就只能依靠真正的临床-放射学-病理学相关性来诊断了。在本综述中，我们将重点介绍诊断外科病理学家在胸腺癌的组织病理学评估以及这些肿瘤分期过程中可能遇到的一些挑战。