Desoye G, Schweditsch M O, Pfeiffer K P, Zechner R, Kostner G M
J Clin Endocrinol Metab. 1987 Apr;64(4):704-12. doi: 10.1210/jcem-64-4-704.
In a comprehensive study the concentrations of plasma lipids and lipo- and apolipoproteins were measured in 24 nonpregnant women (control) and longitudinally in 42 women throughout gestation and postpartum. The results were correlated with hCG, 17 beta-estradiol (E2), progesterone (PG), human placental lactogen (hPL), and insulin levels by time series analysis. Insulin concentrations were constant until week 25 and increased thereafter. Plasma E2, PG, and hPL as well as plasma lipid levels rose continuously during gestation. Apolipoproteins AI, AII, and B concentrations increased until weeks 25, 28, and 32, respectively, and remained constant until term. Low density lipoprotein cholesterol reached maximum levels at week 36. High density lipoprotein cholesterol exhibited a triphasic behavior, with maximum levels at week 25, a fall until week 32, and maintenance of the level until term. Time series analysis revealed positive correlations with E2, PG, and hPL. These results provide evidence that apoprotein concentrations undergo pronounced serial changes during gestation, which in part might be due to the effect of E2. Furthermore, the importance of hPL as a determinant of the plasma levels of total and free cholesterol, triglycerides, and phospholipids is now documented.
在一项综合性研究中，对24名未怀孕女性（对照组）的血浆脂质、脂蛋白和载脂蛋白浓度进行了测量，并对42名女性在整个妊娠期及产后进行了纵向测量。通过时间序列分析，将结果与hCG、17β-雌二醇（E2）、孕酮（PG）、人胎盘催乳素（hPL）和胰岛素水平进行了关联。胰岛素浓度在第25周前保持恒定，此后升高。血浆E2、PG和hPL以及血浆脂质水平在妊娠期持续上升。载脂蛋白AI、AII和B的浓度分别在第25、28和32周前升高，并在足月前保持恒定。低密度脂蛋白胆固醇在第36周达到最高水平。高密度脂蛋白胆固醇呈现三相变化，在第25周达到最高水平，在第32周前下降，并在足月前维持该水平。时间序列分析显示与E2、PG和hPL呈正相关。这些结果提供了证据，表明载脂蛋白浓度在妊娠期会发生显著的系列变化，部分原因可能是E2的作用。此外，现在已证明hPL作为总胆固醇、游离胆固醇、甘油三酯和磷脂血浆水平的决定因素的重要性。
