Ylikorkala O, Kivinen S, Rönnberg L, Viinikka L
J Clin Endocrinol Metab. 1980 Jul;51(1):155-7. doi: 10.1210/jcem-51-1-155.
To study the role of PRL in the regulation of the production of 17 beta-estradiol, progesterone, testosterone, and human placental lactogen (hPL), 11 healthy women were given 150 mg sulpiride daily for 14 days, beginning between weeks 6--9 of normal gestation. Plasma PRL, estradiol, progesterone, testosterone, and hPL were measured before and 1 and 2 weeks after the start of sulpiride treatment, and the results were compared with those from 16 control women who were followed similarly but without sulpiride treatment. Sulpiride treatment induced significant (P less than 0.001) elevations of plasma PRL at 1 week [84.1 +/- 4.9 vs. 23.7 +/- 2.8 ng/ml (mean +/- SE)] and 2 weeks (83.0 +/- 4.1 vs. 31.9 +/- 4.1 ng/ml). No differences were observed in the concentrations of estradiol, progesterone, testosterone, or hPL. Two women treated with sulpiride reported mild uterine contractions, but no spontaneous abortion occurred in either group. It is evident that hyperprolactinemia or sulpiride treatment do not change the circulating concentrations of sex steroids and hPL between 6--11 of normal gestation.
为研究泌乳素（PRL）在调节17β-雌二醇、孕酮、睾酮及人胎盘催乳素（hPL）产生中的作用，选取11名健康女性，于正常妊娠6至9周期间开始，每日给予150毫克舒必利，持续14天。在舒必利治疗开始前、治疗1周和2周后，分别测定血浆PRL、雌二醇、孕酮、睾酮及hPL，并将结果与16名同样接受随访但未接受舒必利治疗的对照女性的结果进行比较。舒必利治疗在1周时[84.1±4.9 vs. 23.7±2.8纳克/毫升（均值±标准误）]和2周时（83.0±4.1 vs. 31.9±4.1纳克/毫升）引起血浆PRL显著升高（P<0.001）。雌二醇、孕酮、睾酮或hPL的浓度未观察到差异。两名接受舒必利治疗女性报告有轻度子宫收缩，但两组均未发生自然流产。显然，高泌乳素血症或舒必利治疗不会改变正常妊娠6至11周期间性类固醇和hPL的循环浓度。
