Tian Zhen, Zhou Dongsheng, Jiang Rui, Zhou Bin
Department of Oncology, Huishan Third People's Hospital of Wuxi, Wuxi, Jiangsu 214183, P.R. China.
Oncol Lett. 2024 Jul 12;28(3):434. doi: 10.3892/ol.2024.14567. eCollection 2024 Sep.
Adhesion molecule with IgG-like domain 2 (AMIGO2) is a novel scaffold protein initially identified in cerebellar granule neurons, and inhibits apoptosis of neurons. It is also widely expressed in various malignant tumors, including gastric cancer, colorectal carcinoma, ovarian cancer, prostate cancer and melanoma. During the past decades, it has been revealed that AMIGO2 can act as an oncogene, participating in tumor occurrence and development, for example by inhibiting apoptosis, accelerating cell proliferation, migration and adhesion, and promoting tumor metastasis and drug resistance. The present review discusses the recent advancements regarding AMIGO2 in the field of cancer, emphasizing its related molecular mechanisms to identify novel therapeutic strategies targeting AMIGO2 for cancer treatment in the future.
含IgG样结构域2的黏附分子（AMIGO2）是一种最初在小脑颗粒神经元中发现的新型支架蛋白，可抑制神经元凋亡。它也广泛表达于各种恶性肿瘤中，包括胃癌、结直肠癌、卵巢癌、前列腺癌和黑色素瘤。在过去几十年中，已发现AMIGO2可作为一种癌基因，参与肿瘤的发生和发展，例如通过抑制凋亡、加速细胞增殖、迁移和黏附，以及促进肿瘤转移和耐药性。本综述讨论了癌症领域中关于AMIGO2的最新进展，强调其相关分子机制，以便未来确定针对AMIGO2的新型癌症治疗策略。
