Abdur Raheem Juwairiah, Unnisa Arshiya, Iqubal Mohammed
Department of Internal Medicine, Deccan College of Medical Sciences, Hyderabad, IND.
Cureus. 2022 Mar 11;14(3):e23076. doi: 10.7759/cureus.23076. eCollection 2022 Mar.
Dapsone, which is used for treating dermatological conditions, can lead to neutropenia. Especially, resistant neutropenia makes patients vulnerable to invasive infections, indicating a medical emergency. Febrile neutropenia secondary to dapsone intake should be treated promptly before the development of sepsis, which may lead to shock and death. In addition, necrotizing fasciitis is a severe and potentially fatal soft-tissue infection that rarely develops in healthy individuals with skin lesions. In this report, we present a case of a patient with no comorbidities who presented with necrotizing fasciitis and neutropenia with a history of dapsone intake.
用于治疗皮肤病的氨苯砜可导致中性粒细胞减少。尤其是耐药性中性粒细胞减少会使患者易发生侵袭性感染，这是一种医疗急症。氨苯砜摄入继发的发热性中性粒细胞减少应在发生败血症之前迅速治疗，败血症可能导致休克和死亡。此外，坏死性筋膜炎是一种严重且可能致命的软组织感染，在有皮肤病变的健康个体中很少发生。在本报告中，我们介绍了一例无合并症的患者，该患者因有氨苯砜摄入史而出现坏死性筋膜炎和中性粒细胞减少。
