Infectious Diseases Service, Federal University of Paraíba, João pessoa, PB, Brazil.
Braz J Infect Dis. 2009 Apr;13(2):158-60. doi: 10.1590/s1413-86702009000200018.
Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone and clofazimine. However, adverse effects can cause the patient to abandon treatment. We report on a patient who presented agranulocytosis and hemolytic anemia associated with this treatment regime. We also examined the importance of laboratory exams for diagnosis and follow-up of the patient, and for early detection of adverse effects,with a view to improving adhesion to treatment and contributing to the eradication of Hansen's disease as a public health issue.
多药联合疗法（WHO/MDT）在多菌型麻风病中的治疗方案包括利福平、氨苯砜和氯法齐明。然而，不良反应可能导致患者停止治疗。我们报告了一例因该治疗方案出现粒细胞缺乏症和溶血性贫血的患者。我们还研究了实验室检查在诊断和随访患者、早期发现不良反应方面的重要性，以期提高治疗依从性，为消除作为公共卫生问题的麻风病做出贡献。
