Naqvi Syed, Schuldt Anastasia, Yousaf Amman, Muhammad Shoaib, Cabrera Diego
Internal Medicine, University of Kentucky College of Medicine, Kentucky, USA.
Internal Medicine, McLaren Flint, Flint, USA.
Cureus. 2022 Mar 19;14(3):e23327. doi: 10.7759/cureus.23327. eCollection 2022 Mar.
Small cell carcinoma of the larynx is a rare form of neuroendocrine carcinoma. Clinical and radiological properties are similar to other laryngeal cancers, prompting histopathology examination. Symptoms include sore throat, dysphagia, odynophagia, and weight loss. Multiple management options have been demonstrated in the literature. However, combined radiation and chemotherapy have proven to improve survival. Unfortunately, the prognosis for this cancer is dismal, as survival from diagnosis rarely exceeds two years. In this article, we present a 64-year-old female patient who presented with a sore throat and was diagnosed with primary small cell cancer of the larynx. Despite the relapse after the initial four cycles of chemotherapy with carboplatin and etoposide, our patient responded well to nivolumab and ipilimumab and is still in remission on a six-month follow-up.
喉小细胞癌是神经内分泌癌的一种罕见形式。其临床和影像学特征与其他喉癌相似，因此需要进行组织病理学检查。症状包括咽痛、吞咽困难、吞咽痛和体重减轻。文献中已证实有多种治疗方案。然而，放疗和化疗联合已被证明可提高生存率。不幸的是，这种癌症的预后很差，因为从诊断开始的生存期很少超过两年。在本文中，我们介绍了一位64岁的女性患者，她因咽痛就诊，被诊断为原发性喉小细胞癌。尽管在最初四个周期的卡铂和依托泊苷化疗后出现复发，但我们的患者对纳武单抗和伊匹单抗反应良好，在六个月的随访中仍处于缓解状态。
