Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers.

OBJECTIVES

To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers.

METHODS

The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO nanoparticles were added to the composite resin as antibacterial filler. Experimental composite resin was manually prepared by adding ingredients. The resin matrix consisted of two mixed monomers, bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate, diketone as the photo initiator, and N, N-dimethylaminoethyl methacrylate as a coinitiator. The antibacterial efficacy against , , , and spp. bacterial strains was tested using the microdilution method keeping commercially available 3M Filtek Z250 restorative composite as control.

RESULTS

The experimental dental composite demonstrated 99.503% efficacy against , 99.441% efficacy against , 99.416% efficacy against , and 99.233% efficacy against spp.

CONCLUSION

Integrating cerium oxide nanoparticles as fillers into dental composite resin can be promising in terms of antibacterial activity, provided furthermore study has to be conducted to examine other properties. . Previous studies attempted adding CeO nanoparticles into acrylic resins that showed improvement in mechanical properties, but literature is nil on the dental composite resin and cerium oxide nanoparticles. This study demonstrates the development of an experimental antibacterial dental composite resin that can resolve most of the problems related to secondary caries around dental composite restorations.