Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Gansu Province, School of Stomatology, Lanzhou University, Lanzhou 730000, PR China.
Department of Stomatology, The 940th Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army, Lanzhou 730050, PR China.
Dent Mater. 2022 Oct;38(10):e266-e274. doi: 10.1016/j.dental.2022.08.010. Epub 2022 Sep 2.
The purpose of this study was to synthesize boron nitride nanosheets modified with zinc oxide nanoparticles (BNNSs/ZnO) and incorporate them as a novel inorganic filler to get an antibacterial dental resin composite.
The BNNSs/ZnO nanocomposites were synthesized via the hydrothermal method and characterized by Field Emission Scanning Electron Microscope (FESEM), Transmission Electron Microscopy (TEM), Energy Dispersive Spectrometer (EDS), X-ray Diffraction (XRD) and Fourier Transform-Infrared (FTIR) Spectroscopy. The BNNSs/ZnO or BNNSs were added into the experimental dental composite with different proportions, respectively. The mechanical and physical properties of the modified dental composite were evaluated. Their antibacterial activities were also assessed by quantitative analysis using Streptococcus mutans (S. mutans).
The BNNSs/ZnO nanocomposites were successfully synthesized, and the growth of ZnO nanoparticles (ZnO NPs) on boron nitride nanosheets was confirmed. The flexural strength (FS), flexural modulus (FM) and the compressive strength (CS) of all modified resin composites showed no change compared to the control group. The curing depth, degree of conversion, water absorption and solubility of the modified composites were still within the clinical requirement. The antibacterial rates of the modified composites were significantly increased compared to the control group, which can reach 98 % when 0.5 % BNNSs/ZnO was added.
The modified dental resin composite with novel BNNSs or BNNSs/ZnO fillers shows significantly high antibacterial activity with suitable physicochemical and mechanical properties.
本研究旨在合成氮化硼纳米片修饰氧化锌纳米粒子（BNNSs/ZnO），并将其作为一种新型无机填料，制备一种具有抗菌性能的牙科树脂复合材料。
采用水热法合成 BNNSs/ZnO 纳米复合材料，并通过场发射扫描电子显微镜（FESEM）、透射电子显微镜（TEM）、能谱仪（EDS）、X 射线衍射（XRD）和傅里叶变换红外光谱（FTIR）对其进行了表征。将 BNNSs/ZnO 或 BNNSs 以不同比例加入到实验性牙科复合材料中。评估了改性牙科复合材料的机械和物理性能，并通过定量分析变形链球菌（S. mutans）评估其抗菌活性。
成功合成了 BNNSs/ZnO 纳米复合材料，并证实了 ZnO 纳米粒子（ZnO NPs）在氮化硼纳米片上的生长。与对照组相比，所有改性树脂复合材料的弯曲强度（FS）、弯曲模量（FM）和压缩强度（CS）均无变化。改性复合材料的固化深度、转化率、吸水率和溶解度仍在临床要求范围内。与对照组相比，改性复合材料的抗菌率显著提高，当添加 0.5% BNNSs/ZnO 时，抗菌率可达 98%。
具有新型 BNNSs 或 BNNSs/ZnO 填料的改性牙科树脂复合材料具有显著的抗菌活性，同时具有合适的理化和机械性能。
