Hawn Vivian S, Vo Thomas A, Flomenbaum David, Gibralter Richard P
Albert Einstein College of Medicine, 1300 Morris Park Avenue, NY, 10461, Bronx, USA.
Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, 111 East 210th Street, NY, 10467, Bronx, USA.
Am J Ophthalmol Case Rep. 2022 Apr 10;26:101515. doi: 10.1016/j.ajoc.2022.101515. eCollection 2022 Jun.
The objective of the study is to report a case of ocular manifestations in a patient with hydralazine-induced vasculitis.
An 88-year-old female was admitted for lower gastrointestinal bleeding. Nine days after admission, she developed bilateral conjunctival chemosis and injection, which rapidly progressed into grouped blistering eruptions of the periorbital skin, face, and neck. After extensive testing and evaluation, her constellation of findings was diagnosed as hydralazine-induced vasculitis. Treatment with intravenous steroids and discontinuation of hydralazine resulted in improvement of the cutaneous and ocular manifestations. Herein we describe the clinical course of an adult patient with symptoms and signs consistent with hydralazine-induced vasculitis to highlight that ophthalmological manifestations can be the first symptoms in patients with life-threatening dermatological conditions.
To our knowledge, this report is the first case of hydralazine-induced vasculitis initially presenting with ocular manifestations.
本研究的目的是报告1例肼屈嗪诱发的血管炎患者的眼部表现。
一名88岁女性因下消化道出血入院。入院9天后，她出现双侧结膜水肿和充血，迅速发展为眶周皮肤、面部和颈部的成簇水疱性皮疹。经过广泛的检查和评估，她的一系列检查结果被诊断为肼屈嗪诱发的血管炎。静脉注射类固醇治疗并停用肼屈嗪后，皮肤和眼部表现有所改善。在此，我们描述了1例成年患者的临床病程，其症状和体征与肼屈嗪诱发的血管炎一致，以强调眼部表现可能是危及生命的皮肤病患者的首发症状。
据我们所知，本报告是首例以眼部表现为首发症状的肼屈嗪诱发的血管炎病例。
