Marin Loris, Ambrosini Guido, Noventa Marco, Filippi Flavia, Ragazzi Eugenio, Dessole Francesco, Capobianco Giampiero, Andrisani Alessandra
Department of Women's and Children's Health, University of Padua, Padua 35100, Italy.
Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua 35100, Italy.
Int J Endocrinol. 2022 Apr 12;2022:6331657. doi: 10.1155/2022/6331657. eCollection 2022.
GnRH agonists (GnRHa) are a useful tool for pretreatment before artificial endometrial preparation for frozen-thawed embryo-transfer (FET). Their prolonged administration has been associated with thyroid dysfunction, both hyper and hypothyroidism. The aim of this study is to investigate the impact of GnRHa administration on thyroid function in women undergoing artificial endometrial preparation. Seventy-eight euthyroid women undergoing endometrial preparation with hormone replacement for FET were retrospectively reviewed. They were divided into two groups according to pretreatment with GnRHa (group A, 42 women) or with an oral contraceptive (group B, 36 women). Group A was subsequently divided into two subgroups according to thyroid autoimmunity presence. Thyroid function has been evaluated and compared among groups and subgroups. Our results did not show any statistically significant differences in age, body mass index, and basal thyroid stimulating hormone (TSH). Total estradiol dosage, duration of treatment, and endometrial thickness were comparable among groups. When TSH was measured 14 days after embryo transfer, no significant differences between the two groups were reported. Among women of group A, TSH was significantly higher only in women with thyroid autoimmunity. GnRHa seems to be associated with thyroid dysfunction in women with thyroid autoimmunity undergoing hormone replacement therapy for FET.
促性腺激素释放激素激动剂（GnRHa）是冻融胚胎移植（FET）人工子宫内膜准备前预处理的一种有用工具。其长期使用与甲状腺功能障碍有关，包括甲状腺功能亢进和减退。本研究的目的是调查GnRHa给药对接受人工子宫内膜准备的女性甲状腺功能的影响。回顾性分析了78例接受激素替代进行FET子宫内膜准备的甲状腺功能正常的女性。根据是否用GnRHa预处理将她们分为两组（A组，42例女性）或口服避孕药组（B组，36例女性）。A组随后根据是否存在甲状腺自身免疫分为两个亚组。对各组和亚组的甲状腺功能进行了评估和比较。我们的结果显示，在年龄、体重指数和基础促甲状腺激素（TSH）方面没有任何统计学上的显著差异。各组间总雌二醇剂量、治疗持续时间和子宫内膜厚度相当。胚胎移植后14天测量TSH时，两组之间没有报告显著差异。在A组女性中，仅甲状腺自身免疫的女性TSH显著更高。对于接受FET激素替代治疗的甲状腺自身免疫女性，GnRHa似乎与甲状腺功能障碍有关。
