Endashaw Hareru Habtamu, Sisay Daniel, Kassaw Chalachew, Kassa Reta
School of Public Health, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Department of Psychiatry, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
SAGE Open Med. 2022 Apr 19;10:20503121221090472. doi: 10.1177/20503121221090472. eCollection 2022.
This study aimed at assessing the prevalence of antibiotics non-adherence and its associated factor among households in southern Ethiopia.
A community-based cross-sectional study was conducted among 323 randomly selected households in Wenago town. To collect the data, structured questionnaire was used. Categorical variables were represented by frequency and percentage. For continuous variables, the mean value and standard deviation were used. Bivariate and multivariate logistic regression analyses were used to identify factors related to antibiotic non-adherence. Finally, for significant factors with -values less than 0.05, the adjusted odds ratio with 95% confidence interval was calculated and evaluated.
The prevalence of antibiotic non-adherence in the household was 194 (60.1%) (95% confidence interval = 55.1-65.6). Remission of symptoms (63%) is one of the top reasons for antibiotic non-adherence in the home. Male sex (adjusted odds ratio = 1.77, 95% confidence interval = 1.03-3.08), lower educational status (adjusted odds ratio = 3.42, 95% confidence interval = 1.51-7.75; adjusted odds ratio = 2.37, confidence interval = 1.12-5.02), poor attitude toward antibiotics use (adjusted odds ratio = 1.89; 95% confidence interval = 1.23-3.04), poor knowledge about antibiotics use (adjusted odds ratio = 1.34; 95% confidence interval = 1.11-2.39), and no-prescription information from pharmacy (adjusted odds ratio = 2.02, 95% confidence interval = 1.09-3.72) were all associated with non-adherence. While no medication discomfort (adjusted odds ratio = 0.31, 95% confidence interval = 0.178-0.56) had a negative effect on non-adherence.
In this study, antibiotic non-adherence was considerably high among the participants. Being male, lower educational status, poor attitude, poor knowledge, no-prescription information from pharmacy/druggist, and medication discomfort were related with antibiotic non-adherence. As a result, community service providers must provide relevant prescription information as well as appropriate counseling to antibiotic non-adherent patients.
本研究旨在评估埃塞俄比亚南部家庭中抗生素不依从性的患病率及其相关因素。
在韦纳戈镇对323个随机选择的家庭进行了一项基于社区的横断面研究。为收集数据，使用了结构化问卷。分类变量用频率和百分比表示。对于连续变量，使用平均值和标准差。采用双变量和多变量逻辑回归分析来确定与抗生素不依从性相关的因素。最后，对于P值小于0.05的显著因素，计算并评估调整后的比值比及95%置信区间。
家庭中抗生素不依从性的患病率为194例（60.1%）（95%置信区间=55.1-65.6）。症状缓解（63%）是家庭中抗生素不依从的主要原因之一。男性（调整后的比值比=1.77，95%置信区间=1.03-3.08）、教育程度较低（调整后的比值比=3.42，95%置信区间=1.51-7.75；调整后的比值比=2.37，置信区间=1.12-5.02）、对抗生素使用态度不佳（调整后的比值比=1.89；95%置信区间=1.23-3.04）、对抗生素使用知识不足（调整后的比值比=1.34；95%置信区间=1.11-2.39）以及没有从药房获得处方信息（调整后的比值比=2.02，95%置信区间=1.09-3.72）均与不依从性相关。而没有用药不适（调整后的比值比=0.31，95%置信区间=0.178-0.56）对不依从性有负面影响。
在本研究中，参与者中抗生素不依从性相当高。男性、教育程度较低、态度不佳、知识不足、没有从药房/药剂师处获得处方信息以及用药不适与抗生素不依从性有关。因此，社区服务提供者必须向抗生素不依从的患者提供相关的处方信息以及适当的咨询。
