Department of Pediatrics, Indiana University, Herman B. Wells Center for Pediatric Research 1044 W Walnut St, Indianapolis, IN 46202, USA.
Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue CSC K3/803, Madison, WI 53792, USA.
Neurol Clin. 2022 May;40(2):437-453. doi: 10.1016/j.ncl.2021.11.003. Epub 2022 Mar 31.
Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of neurologic function. Technological advancements have greatly expanded our ability to safely maximize tumor resection and design innovative therapeutic trials that take advantage of intracavitary delivery of therapeutic agents after resection. In this article, we review the role of surgical intervention for both low-grade and high-grade gliomas and the innovations that are driving and expanding the role of surgery in this therapeutically challenging group of malignancies.
神经胶质瘤是成人中最常见的内在脑肿瘤。虽然最大限度地切除肿瘤可以提高生存率,但这必须与保护神经功能相平衡。技术进步极大地提高了我们安全地最大限度切除肿瘤并设计创新治疗试验的能力,这些试验利用切除后腔内递药的优势。本文综述了手术干预在低级别和高级别神经胶质瘤中的作用,以及推动和扩大手术在这组治疗挑战性恶性肿瘤中作用的创新。