Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Research Center for Experimental and Applied Pharmaceutical Sciences, Urmia University of Medical Sciences, Urmia, Iran.
J Food Biochem. 2022 Sep;46(9):e14212. doi: 10.1111/jfbc.14212. Epub 2022 Apr 25.
Hesperetin, mainly found in citrus honey, has antioxidant, anti-inflammatory, and antiviral properties. Recently, the effect of hesperetin on different aspects of SARS-CoV-2 infection such as viral entry, replication, and inflammatory responses has attracted a lot of attention. However, the exact molecular mechanism for its effects on SARS-CoV-2 infection is not stated. The PI3K/AKT signaling pathway is an intracellular pathway involved in cell proliferation, protein synthesis, and response to environmental changes. Since the role of this pathway in the pathogenesis of SARS-CoV-2 has recently been considered, this letter assumes the probable role of this pathway in the function of hesperetin against SARS-CoV-2 infection. PRACTICAL APPLICATIONS: In this paper, we have discussed the therapeutic effects of hesperetin on SARS-CoV-2 infection. Additionally, we have hypothesized the molecular mechanism of hesperetin in suppression of SARS-CoV-2 entry to the host cells, its replication and inhibition of inflammatory responses. Based on this evidence, the pharmacological properties of hesperetin make this natural compound a potential treatment for suppression of SARS-CoV-2 entry into host cells and the subsequent replication of viral particles.
橙皮苷主要存在于柑橘蜂蜜中，具有抗氧化、抗炎和抗病毒特性。最近，橙皮苷对 SARS-CoV-2 感染不同方面的作用，如病毒进入、复制和炎症反应，引起了广泛关注。然而，其对 SARS-CoV-2 感染的确切分子机制尚不清楚。PI3K/AKT 信号通路是一种参与细胞增殖、蛋白质合成和对环境变化反应的细胞内途径。由于该途径在 SARS-CoV-2 发病机制中的作用最近已被考虑，本函假设该途径在橙皮苷抑制 SARS-CoV-2 感染中的可能作用。实际应用：在本文中，我们讨论了橙皮苷对 SARS-CoV-2 感染的治疗作用。此外，我们假设了橙皮苷抑制 SARS-CoV-2 进入宿主细胞、复制和抑制炎症反应的分子机制。基于这些证据，橙皮苷的药理学特性使这种天然化合物成为抑制 SARS-CoV-2 进入宿主细胞和随后复制病毒颗粒的潜在治疗方法。
