Purdue G F, Hunt J L, Gillespie R W, Hansbrough J F, Dominic W J, Robson M C, Smith D J, MacMillan B G, Waymac J P, Herndon D N
J Trauma. 1987 Feb;27(2):155-7. doi: 10.1097/00005373-198702000-00010.
During the past 2 years a multicenter study was performed comparing Biobrane (Woodroof) and frozen cadaver allograft as temporary dressings on freshly excised full-thickness burns before the application of autograft. Each biologic dressing was evaluated with respect to the other on the same patient. Seventy-one patients were evaluated. The mean burn size was 35 +/- 20% with a mean full-thickness burn of 28 +/- 20%. Mean patient age was 34 +/- 21 years. Overall survival was 82%. The mean time of wound coverage was 10.2 +/- 6.7 days. There was no significant difference in the number of dressing changes, area changed, purulence, autograft take, and final results between allograft- and Biobrane-covered sites. There were no complications following use of either Biobrane or allograft. We conclude that Biobrane is as effective as frozen human cadaver allograft for the temporary coverage of freshly excised full-thickness burn wounds before autografting.
在过去两年中，我们进行了一项多中心研究，比较了生物膜（伍德洛夫）和冷冻尸体同种异体移植物作为自体移植前新鲜切除的全层烧伤创面的临时敷料的效果。在同一患者身上对每种生物敷料进行相互评估。共评估了71例患者。平均烧伤面积为35±20%，平均全层烧伤面积为28±20%。患者平均年龄为34±21岁。总体生存率为82%。创面覆盖的平均时间为10.2±6.7天。同种异体移植物覆盖部位和生物膜覆盖部位在换药次数、换药面积、脓性分泌物、自体移植成功率及最终结果方面无显著差异。使用生物膜或同种异体移植物均未出现并发症。我们得出结论，在自体移植前，生物膜在临时覆盖新鲜切除的全层烧伤创面方面与冷冻人尸体同种异体移植物同样有效。
