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寻找理想的临时皮肤替代物：AWBAT Plus，一种组合产品伤口敷料医疗器械。

The Search for an Ideal Temporary Skin Substitute: AWBAT Plus, a Combination Product Wound Dressing Medical Device.

作者信息

Woodroof E Aubrey, Phipps Richard P, Greenwood John E, Hickerson William, Herndon David

出版信息

Eplasty. 2010 Sep 15;10:e60.

PMID:20862296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2941189/
Abstract

OBJECTIVE

To create an ideal temporary skin substitute.

METHODS

Temporary skin substitute (Biobrane, AWBAT and AWBAT Plus) porosity, 3D matrix, and biochemical composition were evaluated for impact on healing wounds (pain, fluid accumulation, infection, and time to heal). Twenty-four Sprague-Dawley [H1a: (SD) CVF] rats were used to measure the histology of healed full-thickness wounds. Tissue culture methods were used to measure the influence of Immuno-10 on human dermal fibroblasts: proliferation, collagen, and alpha-smooth muscle actin.

RESULTS

In full-thickness wounds (rats), histological evidence suggests better reepithelialization of wounds covered with AWBAT Plus than those with AWBAT. Tissue culture techniques revealed that key biological additives to AWBAT Plus stimulated human dermal fibroblast growth, collagen synthesis, and alpha-smooth muscle actin production. Human keratinocyte growth was also promoted by a key biological element in AWBAT Plus. Interestingly, human mesenchymal stem cells grew well on the AWBAT Plus membrane. Clinically, AWBAT Plus protected widely meshed autograft, which healed more uniformly and faster than cadaver allograft.

CONCLUSION

AWBAT Plus shows a great promise as a major advancement in wound care.

摘要

目的

创建一种理想的临时皮肤替代物。

方法

评估临时皮肤替代物（生物膜、AWBAT和AWBAT Plus）的孔隙率、三维基质和生化组成对伤口愈合（疼痛、积液、感染和愈合时间）的影响。使用24只斯普拉格-道利[H1a:（SD）CVF]大鼠测量全层愈合伤口的组织学情况。采用组织培养方法测量Immuno-10对人真皮成纤维细胞的影响：增殖、胶原蛋白和α-平滑肌肌动蛋白。

结果

在全层伤口（大鼠）中，组织学证据表明，与AWBAT覆盖的伤口相比，AWBAT Plus覆盖的伤口上皮再形成情况更好。组织培养技术表明，AWBAT Plus中的关键生物添加剂可刺激人真皮成纤维细胞生长、胶原蛋白合成和α-平滑肌肌动蛋白生成。AWBAT Plus中的一种关键生物成分还能促进人角质形成细胞生长。有趣的是，人间充质干细胞在AWBAT Plus膜上生长良好。临床上，AWBAT Plus可保护广泛网状自体移植物，其愈合比尸体同种异体移植物更均匀、更快。

结论

AWBAT Plus作为伤口护理领域的一项重大进展，显示出巨大的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/a686b5b75a13/eplasty10e60_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/f901e89391d5/eplasty10e60_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/12a10ccdf921/eplasty10e60_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/1743cd5fc414/eplasty10e60_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/17599e5237d9/eplasty10e60_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/f6fc6409145a/eplasty10e60_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/30e08797d3e6/eplasty10e60_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/02b7a95fd0ff/eplasty10e60_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/ddabc1d3f0fc/eplasty10e60_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/878261c08af2/eplasty10e60_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/a686b5b75a13/eplasty10e60_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/f901e89391d5/eplasty10e60_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/12a10ccdf921/eplasty10e60_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/1743cd5fc414/eplasty10e60_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/17599e5237d9/eplasty10e60_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/f6fc6409145a/eplasty10e60_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/30e08797d3e6/eplasty10e60_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/02b7a95fd0ff/eplasty10e60_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/ddabc1d3f0fc/eplasty10e60_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/878261c08af2/eplasty10e60_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939d/2941189/a686b5b75a13/eplasty10e60_fig10.jpg

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