State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan University, Chengdu, China.
Drug Deliv. 2022 Dec;29(1):1272-1281. doi: 10.1080/10717544.2022.2027572.
One of the most common complications of cancer chemotherapy is oral mucositis (OM), a serious kind of oral ulceration, but its effective treatment remains a serious challenge. In this study, we used deoxycholic acid and fucoidan to prepare inflammation-targeting nanomicelles (FD), because fucoidan can target inflammation due to its high binding affinity for P-selectin. The hydrophobic anti-inflammatory drug cannabidiol (CBD) was then loaded into the hydrophobic core of FD. The resulting CBD-loaded FD micelles (CBD/FD) had uniform particle size and morphology, as well as favorable serum stability. Moreover, administration of the FD micelles intravenous injection or dripping in an OM mouse model enhanced the accumulation and retention of CBD. CBD/FD also showed a better anti-inflammatory effect compared to free CBD after local or systemic administration , while they accelerated OM healing and inhibited Ly6G inflammatory cell infiltration and NF-κB nuclear transcription. Our results show that CBD/FD nanomicelles are a promising agent for OM treatment.
癌症化疗最常见的并发症之一是口腔黏膜炎（OM），一种严重的口腔溃疡，但有效的治疗方法仍然是一个严峻的挑战。在这项研究中，我们使用脱氧胆酸和褐藻聚糖制备炎症靶向纳米胶束（FD），因为褐藻聚糖由于其与 P 选择素的高结合亲和力而具有靶向炎症的能力。然后将疏水性抗炎药物大麻二酚（CBD）加载到 FD 的疏水性核心中。所得的负载 CBD 的 FD 胶束（CBD/FD）具有均匀的粒径和形态，以及良好的血清稳定性。此外，在 OM 小鼠模型中静脉注射或滴注 FD 胶束可增强 CBD 的蓄积和保留。与局部或全身给药后的游离 CBD 相比，CBD/FD 还显示出更好的抗炎作用，同时它们加速 OM 愈合并抑制 Ly6G 炎性细胞浸润和 NF-κB 核转录。我们的结果表明，CBD/FD 纳米胶束是治疗 OM 的一种有前途的药物。
