Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Division of Oral Medicine, Paranaense University (UNIPAR), Paraná, Brazil.
Oral Dis. 2020 Oct;26(7):1483-1493. doi: 10.1111/odi.13413. Epub 2020 Jun 1.
The aim of this study was to evaluate the clinical, histological, hematological, and oxidative stress effects of cannabidiol (CBD) in mice with induced oral mucositis.
We used 90 mice of the CF-1 strain in which oral mucositis was induced using a protocol with 5-fluorouracil (5-FU) chemotherapy. The animals were divided randomly into 10 study groups. Three groups were treated with different doses of CBD (3, 10, and 30 mg/kg), while 2 were control groups (positive control: 5-FU + mechanical trauma + placebo; and negative control: mechanical trauma + placebo), and 2 experimental times were studied (4 and 7 days). All treatments were by intraperitoneal administration.
In the clinical evaluation, the groups treated with CBD showed less severity of oral lesions compared with the positive control at both experimental times. The intensity of the inflammatory response was also lower in the groups treated with this drug, but there was no statistically significant difference when compared with the positive control. With regard to erythrocyte, leukocyte, and platelet counts and anti-oxidant enzyme activity, the groups treated with CBD showed better results, but only some of these variables showed statistically significant differences.
CBD seems to exert an anti-inflammatory and anti-oxidant activity favoring a faster resolution of oral mucositis in this animal model.
本研究旨在评估大麻二酚（CBD）对诱导口腔黏膜炎的小鼠的临床、组织学、血液学和氧化应激的影响。
我们使用了 90 只 CF-1 品系的小鼠，通过使用氟尿嘧啶（5-FU）化疗的方案诱导口腔黏膜炎。动物被随机分为 10 个研究组。三组接受不同剂量的 CBD（3、10 和 30mg/kg）治疗，两组为对照组（阳性对照：5-FU+机械创伤+安慰剂；阴性对照：机械创伤+安慰剂），并研究了两个实验时间（4 和 7 天）。所有治疗均通过腹腔内给药。
在临床评估中，与阳性对照组相比，在两个实验时间点，接受 CBD 治疗的组的口腔病变严重程度较低。与阳性对照组相比，该药物治疗组的炎症反应强度也较低，但无统计学差异。关于红细胞、白细胞和血小板计数以及抗氧化酶活性，接受 CBD 治疗的组表现出更好的结果，但只有一些变量显示出统计学差异。
CBD 似乎在这种动物模型中具有抗炎和抗氧化作用，有利于更快地缓解口腔黏膜炎。
