（±）- 苦竹宁的全合成：基于 6-自由基环化反应。
Total synthesis of (±)-mersicarpine following a 6- radical cyclization.
机构信息
Department of Applied Chemistry, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan.
出版信息
Org Biomol Chem. 2022 Aug 10;20(31):6193-6195. doi: 10.1039/d2ob00620k.
PMID:35467680
Abstract
Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-]indole scaffold bearing the all-carbon quaternary stereocenter.
摘要
描述了从二乙基 4-氧代戊二酸酯全合成外消旋梅尔西卡品。该合成路线利用 2-吲哚基自由基环化反应构建了含有全碳季碳立体中心的吡啶并[1,2-]吲哚骨架。
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