培养的表皮细胞中的类天疱疮和天疱疮抗原。
Pemphigoid and pemphigus antigens in cultured epidermal cells.
作者信息
Diaz L A, Marcelo C L
出版信息
Br J Dermatol. 1978 Jun;98(6):631-7. doi: 10.1111/j.1365-2133.1978.tb03581.x.
Abstract
Fractions of IgG from sera of patients with pemphigoid and pemphigus added to monolayer cultures of mouse epidermal cells resulted in a sparse distribution of cells. Direct immunofluorescence studies of these monolayers revealed epidermal cell surface antigens reacting with pemphigoid and pemphigus antibodies. We suggest that these antibodies may bind to epidermal cell surface antigenic molecules which are important in maintaining epidermal cell adhesion in culture.
摘要
将类天疱疮和天疱疮患者血清中的IgG组分添加到小鼠表皮细胞单层培养物中，导致细胞分布稀疏。对这些单层培养物进行的直接免疫荧光研究显示，表皮细胞表面抗原与类天疱疮和天疱疮抗体发生反应。我们认为，这些抗体可能与表皮细胞表面抗原分子结合，而这些分子在维持培养中的表皮细胞黏附中起重要作用。
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