Gonzalez L P
Life Sci. 1987 Mar 2;40(9):899-908. doi: 10.1016/0024-3205(87)90039-7.
Stereotypy induced by high doses of amphetamine has been related to the ability of this drug to increase the release of dopamine in the caudate nucleus and to block its reuptake. Since amphetamine-stimulated dopamine release in the caudate is blocked by acute lesions of the nigrostriatal pathway, the mechanism by which amphetamine acts to produce stereotypy may be dependent upon intact nigrostriatal impulse flow. The present study examined the involvement of nigrostriatal impulse flow in amphetamine stereotypy by determining the effect of acute, bilateral lesions of substantia nigra pars compacta on measures of stimulant-induced stereotypy and motility. Acute nigral lesions did not significantly alter the stereotypy or motility induced by 3.0 or 6.0 mg/kg amphetamine. These results suggest that the observed behavioral effects of amphetamine do not require an intact nigrostriatal pathway, and thus may involve changes in spontaneous release or reuptake of dopamine rather than in changes in impulse-coupled dopamine release.
高剂量苯丙胺诱发的刻板行为与该药物增加尾状核中多巴胺释放及阻断其再摄取的能力有关。由于黑质纹状体通路的急性损伤会阻断苯丙胺刺激的尾状核多巴胺释放，苯丙胺产生刻板行为的作用机制可能依赖于完整的黑质纹状体冲动流。本研究通过测定黑质致密部急性双侧损伤对兴奋剂诱发的刻板行为和运动能力指标的影响，来检验黑质纹状体冲动流在苯丙胺刻板行为中的作用。急性黑质损伤并未显著改变3.0或6.0mg/kg苯丙胺诱发的刻板行为或运动能力。这些结果表明，观察到的苯丙胺行为效应并不需要完整的黑质纹状体通路，因此可能涉及多巴胺自发释放或再摄取的变化，而非冲动偶联多巴胺释放的变化。
