黑质在苯丙胺运动兴奋作用中的角色。
The role of the substantia nigra in the locomotor stimulant action of amphetamine.
作者信息
Costall B, Naylor R J
出版信息
Br J Pharmacol. 1973 Sep;49(1):29-36. doi: 10.1111/j.1476-5381.1973.tb08265.x.
Abstract
- The electrolytic brain lesion technique was used to evaluate the role of the substantia nigra in the mediation of the locomotor stimulant effect of (+)-amphetamine in the rat. The effect upon the results of variations in strain and basal activity levels of the rats was assessed.2. In the immediate postoperative phase the lesioned animals developed spontaneous stereotyped behaviour patterns which were more intense in rats of initially high basal activity. Activity was depressed at this stage and only that of the low activity animals was stimulated by amphetamine.3. After the 2nd postoperative day rats with lesions of the substantia nigra developed hyperactivity, but this was only maintained in rats initially of low basal activity. During this stage the locomotor stimulant effect of amphetamine (1.0 mg/kg) was apparent and after the 9th postoperative day animals generally displayed an increased sensitivity to the drug effect.4. The involvement of the substantia nigra with the control of locomotor activity is indicated but its integrity would not appear essential for the mediation of the locomotor stimulant effects of amphetamine.
摘要
采用电解脑损伤技术评估黑质在介导（+）-苯丙胺对大鼠运动兴奋作用中的作用。评估了大鼠品系和基础活动水平变化对结果的影响。
在术后即刻阶段，损伤动物出现自发的刻板行为模式，最初基础活动高的大鼠中这种模式更强烈。此阶段活动受到抑制，只有低活动动物的活动受到苯丙胺刺激。
术后第2天之后，黑质损伤的大鼠出现多动，但仅在最初基础活动低的大鼠中持续存在。在此阶段，苯丙胺（1.0mg/kg）的运动兴奋作用明显，术后第9天之后动物通常对药物作用表现出更高的敏感性。
表明黑质参与运动活动的控制，但其完整性对于介导苯丙胺的运动兴奋作用似乎并非必不可少。
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