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电离辐射诱导的原发性大鼠肿瘤中c-myc和c-K-ras癌基因的激活。

Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

作者信息

Sawey M J, Hood A T, Burns F J, Garte S J

出版信息

Mol Cell Biol. 1987 Feb;7(2):932-5. doi: 10.1128/mcb.7.2.932-935.1987.

DOI:10.1128/mcb.7.2.932-935.1987
PMID:3547086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365153/
Abstract

An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.

摘要

通过转染在NIH 3T3细胞中检测到活化的K-ras癌基因，在12个由电离辐射诱导的大鼠皮肤肿瘤中的6个中通过Southern印迹分析检测到该基因。12个肿瘤中的10个的DNA还显示出c-myc基因扩增和限制性多态性。在癌基因激活模式中观察到组织特异性证据，三种透明细胞癌中的每一种都表现出c-myc和K-ras癌基因的激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/bbaecaa46248/molcellb00074-0378-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/0d276090ee2f/molcellb00074-0377-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/da279cc7593e/molcellb00074-0377-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/bbaecaa46248/molcellb00074-0378-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/0d276090ee2f/molcellb00074-0377-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/da279cc7593e/molcellb00074-0377-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a25/365153/bbaecaa46248/molcellb00074-0378-a.jpg

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本文引用的文献

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Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.T24膀胱癌转化基因的激活与单个氨基酸变化有关。
Nature. 1982 Dec 23;300(5894):762-5. doi: 10.1038/300762a0.
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