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大麻素受体激动剂 WIN 55,212-2 对高架十字迷宫中遗传性癫痫发作模型的焦虑样行为和运动的影响。

The effect of cannabinoid receptor agonist WIN 55,212-2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze.

机构信息

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

Laboratory of Behavioral Physiology, Human Physiology Section "Giuseppe Pagano", Department of Biomedicine, Neuroscience and Advanced Diagnosistics (BIND), University of Palermo, Palermo, Italy.

出版信息

CNS Neurosci Ther. 2022 Aug;28(8):1268-1270. doi: 10.1111/cns.13848. Epub 2022 Apr 26.

DOI:10.1111/cns.13848
PMID:35470960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9253729/
Abstract

GAERS and NEC rats were treated with cannabinoid 1/2 receptor agonist WIN 55,212-2 2 mg/kg and tested on the Elevated Plus-Maze.

摘要

GAERS 和 NEC 大鼠接受大麻素 1/2 受体激动剂 WIN 55,212-2（2 毫克/千克）治疗，并在高架十字迷宫上进行测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca58/9253729/15af131f5d73/CNS-28-1268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca58/9253729/15af131f5d73/CNS-28-1268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca58/9253729/15af131f5d73/CNS-28-1268-g002.jpg

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本文引用的文献

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Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg.1 型大麻素受体的正变构调节可减少斯特拉斯堡遗传性癫痫大鼠的棘波和尖波放电。
Neuropharmacology. 2021 Jun 1;190:108553. doi: 10.1016/j.neuropharm.2021.108553. Epub 2021 Apr 9.
2
Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality.失神发作及其与抑郁和焦虑的关系：双向证据。
Epilepsia. 2021 May;62(5):1041-1056. doi: 10.1111/epi.16862. Epub 2021 Mar 10.
3
Endocannabinoid-serotonin systems interaction in health and disease.
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CNS Neurosci Ther. 2024 Mar;30(3):e14443. doi: 10.1111/cns.14443. Epub 2023 Sep 2.
4
Chronic exposure to a synthetic cannabinoid alters cerebral brain metabolism and causes long-lasting behavioral deficits in adult mice.慢性暴露于合成大麻素会改变成年老鼠的大脑代谢，并导致长期的行为缺陷。
J Neural Transm (Vienna). 2023 Aug;130(8):1013-1027. doi: 10.1007/s00702-023-02607-8. Epub 2023 Feb 28.
内源性大麻素-血清素系统在健康和疾病中的相互作用。
Prog Brain Res. 2021;259:83-134. doi: 10.1016/bs.pbr.2021.01.003. Epub 2021 Jan 22.
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Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.对失神发作的病理生理学、共病和治疗的临床和实验见解。
Brain. 2020 Aug 1;143(8):2341-2368. doi: 10.1093/brain/awaa072.
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Neuropharmacology. 2016 Sep;108:292-304. doi: 10.1016/j.neuropharm.2016.04.016. Epub 2016 Apr 13.
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Eur J Neurosci. 2016 Jan;43(1):25-40. doi: 10.1111/ejn.13110. Epub 2015 Nov 25.
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A genetic epilepsy rat model displays endophenotypes of psychosis.一种遗传性癫痫大鼠模型表现出精神病的内表型。
Neurobiol Dis. 2010 Jul;39(1):116-25. doi: 10.1016/j.nbd.2010.02.001. Epub 2010 Feb 11.
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Epilepsia. 2010 Aug;51(8):1511-21. doi: 10.1111/j.1528-1167.2009.02510.x. Epub 2010 Feb 3.