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大麻素受体激动剂 WIN 55,212-2 对高架十字迷宫中遗传性癫痫发作模型的焦虑样行为和运动的影响。

The effect of cannabinoid receptor agonist WIN 55,212-2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze.

机构信息

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

Laboratory of Behavioral Physiology, Human Physiology Section "Giuseppe Pagano", Department of Biomedicine, Neuroscience and Advanced Diagnosistics (BIND), University of Palermo, Palermo, Italy.

出版信息

CNS Neurosci Ther. 2022 Aug;28(8):1268-1270. doi: 10.1111/cns.13848. Epub 2022 Apr 26.

Abstract

GAERS and NEC rats were treated with cannabinoid 1/2 receptor agonist WIN 55,212-2 2 mg/kg and tested on the Elevated Plus-Maze.

摘要

GAERS 和 NEC 大鼠接受大麻素 1/2 受体激动剂 WIN 55,212-2(2 毫克/千克)治疗,并在高架十字迷宫上进行测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca58/9253729/15af131f5d73/CNS-28-1268-g002.jpg

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本文引用的文献

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Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality.
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Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures.
Neuropharmacology. 2016 Sep;108:292-304. doi: 10.1016/j.neuropharm.2016.04.016. Epub 2016 Apr 13.
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