Section of Neuroscience and Cell Biology, Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy; Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Prog Brain Res. 2021;259:83-134. doi: 10.1016/bs.pbr.2021.01.003. Epub 2021 Jan 22.
Endocannabinoid (eCB) and serotonin (5-HT) neuromodulatory systems work both independently and together to finely orchestrate neuronal activity throughout the brain to strongly sculpt behavioral functions. Surprising parallelism between the behavioral effects of 5-HT and eCB activity has been widely reported, including the regulation of emotional states, stress homeostasis, cognitive functions, food intake and sleep. The distribution pattern of the 5-HT system and the eCB molecular elements in the brain display a strong overlap and several studies report a functional interplay and even a tight interdependence between eCB/5-HT signaling. In this review, we examine the available evidence of the interaction between the eCB and 5-HT systems. We first introduce the eCB system, then we describe the eCB/5-HT crosstalk at the neuronal and synaptic levels. Finally, we explore the potential eCB/5-HT interaction at the behavioral level with the implication for psychiatric and neurological disorders. The precise elucidation of how this neuromodulatory interaction dynamically regulates biological functions may lead to the development of more targeted therapeutic strategies for the treatment of depressive and anxiety disorders, psychosis and epilepsy.
内源性大麻素（eCB）和血清素（5-HT）神经调质系统既独立又协同作用，精细地协调大脑中的神经元活动，强烈塑造行为功能。5-HT 和 eCB 活性的行为效应之间存在广泛报道的惊人平行性，包括情绪状态、应激平衡、认知功能、食物摄入和睡眠的调节。5-HT 系统和 eCB 分子元件在大脑中的分布模式具有很强的重叠性，并且有几项研究报告了 eCB/5-HT 信号之间的功能相互作用，甚至是紧密的相互依存关系。在这篇综述中，我们检查了 eCB 和 5-HT 系统之间相互作用的现有证据。我们首先介绍了 eCB 系统，然后描述了神经元和突触水平上的 eCB/5-HT 串扰。最后，我们探讨了行为水平上潜在的 eCB/5-HT 相互作用及其对精神和神经障碍的影响。精确阐明这种神经调质相互作用如何动态调节生物功能，可能会为治疗抑郁和焦虑障碍、精神病和癫痫等疾病的发展提供更有针对性的治疗策略。
