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在严重急性呼吸冠状病毒病毒 2（SARS-CoV-2）B.1.617.2 德尔塔变异株社区传播期间，将散发性医院集群联系起来：全基因组测序的应用。

Linking sporadic hospital clusters during a community surge of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) B.1.617.2 delta variant: The utility of whole-genome sequencing.

机构信息

Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.

Duke-NUS Medical School, Singapore, Singapore.

出版信息

Infect Control Hosp Epidemiol. 2023 Jun;44(6):1014-1018. doi: 10.1017/ice.2022.106. Epub 2022 Apr 27.

DOI:10.1017/ice.2022.106
PMID:35473629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10262163/
Abstract

Sporadic clusters of healthcare-associated coronavirus disease 2019 (COVID-19) occurred despite intense rostered routine surveillance and a highly vaccinated healthcare worker (HCW) population, during a community surge of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) B.1.617.2 δ (delta) variant. Genomic analysis facilitated timely cluster detection and uncovered additional linkages via HCWs moving between clinical areas and among HCWs sharing a common lunch area, enabling early intervention.

摘要

尽管进行了密集的常规排班监测，且医护人员（HCW）群体的疫苗接种率很高，但在严重急性呼吸冠状病毒 2 型（SARS-CoV-2）B.1.617.2 δ（德尔塔）变异株引发的社区疫情中，仍出现了零星聚集性的与医疗保健相关的 2019 年冠状病毒病（COVID-19）。基因组分析有助于及时发现聚集性病例，并通过在临床区域之间以及在共用午餐区的 HCW 之间移动的 HCW 发现其他关联，从而实现早期干预。

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