Department of Neurology, Neuroimmunology Section, University of Rostock, Gehlsheimer Straße 20, 18147 Rostock, Germany; Ecumenic Hainich Hospital gGmbH, Pfafferode 102, 99974 Mühlhausen, Germany.
Ecumenic Hainich Hospital gGmbH, Pfafferode 102, 99974 Mühlhausen, Germany.
Vaccine. 2022 May 20;40(23):3236-3243. doi: 10.1016/j.vaccine.2022.04.012. Epub 2022 Apr 23.
Infections can have a significant impact on morbidity and mortality in multiple sclerosis (MS) patients. Therefore, vaccinations are of immense importance. If vaccination willingness is to be increased, possible influencing factors should be identified. The aim of the present study was to investigate the status of active immunisation in MS patients in association with sociodemographic, clinical-neurological, psychopathological and personality variables using the NEO-Five Factor Inventory, the Temperament and Character Inventory-Revised and the Hospital Anxiety and Depression Scale.
Four hundred and four MS patients from two German neurological hospitals were examined for their vaccination attitudes, in detail, the general willingness to vaccinate and the current vaccination status of mumps, measles and rubella (MMR) as well as tetanus and influenza. We also looked at the current level of disability in relation to the current vaccination status, as well as possible associated personality and psychopathological variables.
Patients with a complete MMR vaccination status were significantly younger and those with a complete influenza vaccination status were significantly older than those with related incomplete vaccination status. Tetanus vaccination status completeness did not differ depending on age and did not show substantial association with personality scores. However, influenza vaccination completeness was associated with differences in personality and psychopathological variables; extraversion, openness, novelty seeking, harm avoidance and anxiety. A reported general vaccination willingness was significantly correlated with the current completeness of tetanus and influenza vaccinations. Novelty seeking, persistence, extraversion, agreeableness, conscientiousness and neuroticism were found associated with an increased vaccination willingness. Anxiety and depression were not related to general vaccination willingness.
No specific personality trait could be defined on its own in relation to general vaccination willingness or complete vaccination status. Younger patients should be made more aware of influenza vaccination. Reasons for rather low vaccination rates need to be further investigated.
感染会对多发性硬化症（MS）患者的发病率和死亡率产生重大影响。因此，接种疫苗至关重要。如果要提高疫苗接种意愿，就应该确定可能的影响因素。本研究的目的是使用 NEO-Five Factor Inventory、Temperament and Character Inventory-Revised 和 Hospital Anxiety and Depression Scale 调查 MS 患者的主动免疫状况与社会人口统计学、临床神经学、心理病理学和人格变量之间的关系。
对来自德国两家神经病医院的 404 名 MS 患者进行了疫苗接种态度检查，详细了解了他们普遍接种疫苗的意愿以及腮腺炎、麻疹和风疹（MMR）以及破伤风和流感的当前接种情况。我们还研究了当前残疾水平与当前接种状况的关系，以及可能相关的人格和心理病理变量。
完全 MMR 疫苗接种状态的患者明显比未完成 MMR 疫苗接种状态的患者年轻，而完全流感疫苗接种状态的患者明显比未完成 MMR 疫苗接种状态的患者年长。破伤风疫苗接种状态的完整性与年龄无关，与人格评分没有显著关联。然而，流感疫苗接种的完整性与人格和心理病理变量有关；外向性、开放性、求新性、回避伤害和焦虑。报告的一般接种意愿与当前破伤风和流感疫苗接种的完整性显著相关。求新性、坚持性、外向性、宜人性、尽责性和神经质与接种意愿增加有关。焦虑和抑郁与一般接种意愿无关。
不能单独确定与一般接种意愿或完全接种状态相关的特定人格特征。应提高年轻患者对流感疫苗接种的认识。需要进一步调查导致接种率较低的原因。
