School of Physical Education, Shanxi University, No. 92, Wucheng Road, Taiyuan, 030006, Shanxi, China.
Sci Rep. 2022 Apr 26;12(1):6791. doi: 10.1038/s41598-022-10976-5.
Acute high-intensity exercise can affect cardiac health by altering substance metabolism. However, few metabolomics-based studies provide data on the effect of exercise along with myocardial metabolism. Our study aimed to identify metabolic signatures in rat myocardium during acute high-intensity exercise and evaluate their diagnostic potential for sports injuries. We collected rat myocardium samples and subjects' serum samples before and after acute high-intensity exercise for metabolite profiling to explore metabolic alterations of exercise response in the myocardium. Multivariate analysis revealed myocardium metabolism differed before and after acute high-intensity exercise. Furthermore, 6 target metabolic pathways and 12 potential metabolic markers for acute high-intensity exercise were identified. Our findings provided an insight that myocardium metabolism during acute high-intensity exercise had distinct disorders in complex lipids and fatty acids. Moreover, an increase of purine degradation products, as well as signs of impaired glucose metabolism, were observed. Besides, amino acids were enhanced with a certain protective effect on the myocardium. In this study, we discovered how acute high-intensity exercise affected myocardial metabolism and exercise-related heart injury risks, which can provide references for pre-competition screening, risk prevention, and disease prognosis in competitive sports and effective formulation of exercise prescriptions for different people.
急性高强度运动可以通过改变物质代谢来影响心脏健康。然而，很少有基于代谢组学的研究提供关于运动与心肌代谢同时作用的相关数据。本研究旨在鉴定急性高强度运动过程中大鼠心肌的代谢特征，并评估其对运动损伤的诊断潜力。我们收集了大鼠心肌样本和运动前后的血清样本进行代谢组学分析，以探讨心肌对运动反应的代谢变化。多元分析显示，急性高强度运动前后心肌代谢存在差异。此外，还鉴定出 6 条与急性高强度运动相关的目标代谢途径和 12 种潜在的代谢标志物。本研究结果表明，急性高强度运动期间心肌代谢在复杂脂质和脂肪酸方面存在明显紊乱。此外，还观察到嘌呤降解产物增加以及葡萄糖代谢受损的迹象。此外，氨基酸也得到了增强，对心肌具有一定的保护作用。在这项研究中，我们发现了急性高强度运动如何影响心肌代谢和与运动相关的心脏损伤风险，这可为竞技体育中的赛前筛查、风险预防和疾病预后提供参考，并为不同人群制定有效的运动处方。
