Dillon M J, Shah V, Barratt T M
Br Med J. 1978 Jul 15;2(6131):168-70. doi: 10.1136/bmj.2.6131.168.
Renal venous renin activity was measured in 50 children with hypertension. Main renal vein and segmental renal vein sampling was feasible in children as young as 15 months. In all cases in which there was a clear difference in renin secretion between the kidneys--that is, a main vein renin ratio above 1.5--surgery, when undertaken, successfully restored normal blood pressure. Most of the children with main renal vein renin ratios below 1.5 had bilateral disease or apparently normal kidneys. Segmental renal vein sampling contributed useful information additional to that provided by main renal vein measurements and permitted identification of local sources of renin production. In children with renal transplants who developed hypertension renal vein renin measurements helped in determining the cause and facilitating the management of the raised blood pressure.
对50名高血压儿童进行了肾静脉肾素活性测定。在年仅15个月的儿童中进行主肾静脉和节段性肾静脉采样是可行的。在所有肾脏之间肾素分泌存在明显差异的病例中，即主静脉肾素比率高于1.5时，进行手术可成功恢复正常血压。大多数主肾静脉肾素比率低于1.5的儿童患有双侧疾病或肾脏明显正常。节段性肾静脉采样提供了除主肾静脉测量所提供信息之外的有用信息，并有助于确定肾素产生的局部来源。在发生高血压的肾移植儿童中，肾静脉肾素测量有助于确定病因并促进对血压升高的管理。
