光学相干断层扫描在假性剥脱性青光眼诊断中的性能。
Diagnostic Performance of Optical Coherence Tomography for Pseudoexfoliation Glaucoma.
机构信息
Department of Ophthalmology, University of Health Sciences Haydarpasa Education and Research Hospital, Istanbul, Turkey.
出版信息
J Glaucoma. 2022 Aug 1;31(8):651-658. doi: 10.1097/IJG.0000000000002042. Epub 2022 Apr 27.
PRCIS
Lamina cribrosa (LC) thickness and LC curvature index (LCCI) had comparable diagnostic performances with retinal nerve fiber layer (RNFL) thickness in distinguishing eyes with pseudoexfoliation glaucoma (PXG) from those with pseudoexfoliation syndrome (PXS). Bruch's membrane opening-minimum rim width (BMO-MRW) showed the lowest diagnostic performance among all geometric parameters derived from optical coherence tomography (OCT) scans we evaluated.
OBJECTIVE
The aim was to compare the diagnostic performance of different geometric parameters derived from OCT scans (RNFL thickness, LC thickness, LCCI, and BMO-MRW) for distinguishing eyes with PXG from PXS and healthy eyes.
MATERIALS AND METHODS
Fifty-five eyes of 55 patients with PXG, 55 eyes of 55 patients with PXS, and 50 healthy subjects were enrolled in this cross-sectional study. The areas under the receiver operating characteristic curves (AUCs) of RNFL thickness, LC thickness, LCCI and BMO-MRW were calculated and compared.
RESULTS
In discriminating between eyes with PXG from those with PXS, LC thickness [0.930; 95% confidence interval (CI): 0.883-0.978] and global RNFL thickness (0.974; 95% CI: 0.947-0.992) presented comparable AUCs ( P =0.244). In distinguishing subjects with PXG from healthy controls, both LC thickness (0.972; 95% CI: 0.948-0.997) and LCCI (0.983; 95% CI: 0.968-0.998) had comparable AUCs with global RNFL thickness (0.988; 95% CI: 0.974-1.000) ( P =0.094 and 0.239, respectively). Global BMO-MRW had lower AUCs than RNFL thickness (0.839; 95% CI: 0.759-0.920 and 0.897; 95% CI: 0.836-0.958, respectively) in distinguishing PXG from both PXS and healthy controls ( P =0.001 and 0.002, respectively). BMO-MRW also had significantly lower AUCs than both LC thickness and LCCI in distinguishing PXG from healthy controls ( P =0.034 and 0.001, respectively).
CONCLUSION
LC thickness and LCCI had better diagnostic performance than BMO-MRW in distinguishing PXG from PXS and healthy controls, which were comparable to RNFL thickness.
PRCIS
在鉴别假性剥脱综合征（PXS）和假性剥脱性青光眼（PXG）患者的眼中，与视网膜神经纤维层（RNFL）厚度相比，筛板（LC）厚度和 LC 曲率指数（LCCI）具有相当的诊断性能。在我们评估的所有来自光学相干断层扫描（OCT）的几何参数中，Bruch 膜开口最小边缘宽度（BMO-MRW）的诊断性能最低。
目的
比较 OCT 扫描得出的不同几何参数（RNFL 厚度、LC 厚度、LCCI 和 BMO-MRW）在鉴别 PXG 眼与 PXS 和健康眼方面的诊断性能。
材料和方法
本横断面研究纳入了 55 例 PXG 患者的 55 只眼、55 例 PXS 患者的 55 只眼和 50 名健康受试者。计算并比较了 RNFL 厚度、LC 厚度、LCCI 和 BMO-MRW 的受试者工作特征曲线下面积（AUC）。
结果
在鉴别 PXG 眼与 PXS 眼中，LC 厚度[0.930；95%置信区间（CI）：0.883-0.978]和全层 RNFL 厚度（0.974；95%CI：0.947-0.992）具有相当的 AUC（P=0.244）。在鉴别 PXG 患者与健康对照者时，LC 厚度（0.972；95%CI：0.948-0.997）和 LCCI（0.983；95%CI：0.968-0.998）与全层 RNFL 厚度（0.988；95%CI：0.974-1.000）的 AUC 相当（P=0.094 和 0.239，分别）。与 RNFL 厚度（分别为 0.839；95%CI：0.759-0.920 和 0.897；95%CI：0.836-0.958）相比，全层 BMO-MRW 在鉴别 PXG 眼与 PXS 和健康对照者时的 AUC 较低（P=0.001 和 0.002，分别）。BMO-MRW 在鉴别 PXG 眼与健康对照者时的 AUC 也显著低于 LC 厚度和 LCCI（P=0.034 和 0.001，分别）。
结论
与 BMO-MRW 相比，LC 厚度和 LCCI 在鉴别 PXG 眼与 PXS 和健康对照者方面具有更好的诊断性能，与 RNFL 厚度相当。
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