Department of Ophthalmology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, Turkey.
Department of Ophthalmology, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul, Turkey.
Int Ophthalmol. 2022 Jun;42(6):1835-1847. doi: 10.1007/s10792-021-02181-6. Epub 2022 Jan 5.
To compare the correlations between lamina cribrosa (LC) and related structures with Bruch's membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in pseudoexfoliation syndrome (PXS) and different stages of pseudoexfoliation glaucoma (PXG).
This prospective cross-sectional study included 32 PXS eyes of 24 patients and 94 PXG eyes (early-stage (n: 55) and advanced-stage glaucoma (n: 39) of 78 patients. Global and six sectors of RNFL thicknesses and BMO-MRW parameters were measured with enhanced depth imaging (EDI) mode of SD-OCT. Structural parameters; lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD), prelaminar tissue thickness (PLTT), four quadrants of peripapillary choroidal thicknesses (PPCT), and subfoveal choroidal thickness (SFCT) were measured and statistical relationships between the structural parameters have been laid out. We apply the generalized estimating equations method to take into account dependency of right and left eyes.
From PXS to mild and advanced PXG groups LCT and PLTT decrease from 147.29 ± 33.10, 145.62 ± 30.64, 126.30 ± 29.14 and 260.93 ± 185.07, 247.27 ± 142.58, 159.89 ± 86.84, respectively, and LCD varies as 159.89 ± 86.84, 420.88 ± 117.80, and 505.64 ± 183.25. The correlations between LCD, LCT, and PLTT and the stage of the disease are significant. BMO-MRW shows slightly stronger correlations than the RNFL with LC related parameters. SFCT does not exhibit any significant relationship with the stage of the disease. However, PPCT in only the interior quadrant does. The significant correlations between LCD and all quadrants of PPCT is the sign of important anatomic relationship.
These findings show that the BMO-MRW parameter may be more sensitive than RNFL and can safely be used in the diagnosis and follow-up in PXS and PXG, but this result should be supported with longer and larger series.
比较假设有层（LC）和相关结构与布鲁赫膜开口最小边缘宽度（BMO-MRW）和视网膜神经纤维层（RNFL）厚度在假剥脱综合征（PXS）和不同阶段的假剥脱性青光眼（PXG）之间的相关性。
这项前瞻性的横断面研究包括 32 只 PXS 眼（24 例患者）和 94 只 PXG 眼（早期（n=55）和晚期青光眼（n=39）的 78 例患者）。使用 SD-OCT 的增强深度成像（EDI）模式测量全球和六个象限的 RNFL 厚度和 BMO-MRW 参数。测量结构参数：层筛厚度（LCT）、层筛深度（LCD）、前组织厚度（PLTT）、视盘周围脉络膜厚度（PPCT）四个象限和黄斑下脉络膜厚度（SFCT），并列出结构参数之间的统计关系。我们应用广义估计方程方法来考虑右眼和左眼的依赖性。
从 PXS 到轻度和晚期 PXG 组，LCT 和 PLTT 分别从 147.29±33.10、145.62±30.64、126.30±29.14 和 260.93±185.07、247.27±142.58、159.89±86.84 减少，LCD 分别为 159.89±86.84、420.88±117.80 和 505.64±183.25。LCD、LCT 和 PLTT 与疾病阶段之间的相关性具有统计学意义。BMO-MRW 与 LC 相关参数的相关性略强于 RNFL。SFCT 与疾病阶段无显著关系。然而，只有内部象限的 PPCT 才有。LCD 与所有象限的 PPCT 之间的显著相关性表明它们之间存在重要的解剖关系。
这些发现表明，BMO-MRW 参数可能比 RNFL 更敏感，可安全用于 PXS 和 PXG 的诊断和随访，但这一结果需要更长和更大的系列支持。
