胆道手术中的预防性复方新诺明
Prophylactic co-trimoxazole in biliary surgery.
作者信息
Morran C, McNaught W, McArdle C S
出版信息
Br Med J. 1978 Aug 12;2(6135):462-4. doi: 10.1136/bmj.2.6135.462.
Abstract
A double-blind study was conducted to test the prophylactic effect of a single dose of co-trimoxazole on the incidence of septic complications after elective cholecystectomy. Forty-eight patients received co-trimoxazole and 47 placebo. Wound sepsis occurred in 10 (21%) of the controls but in only 2 (4%) of the treated group, and the incidences of pulmonary complications were 49% (23 cases) and 19% (9) respectively. These differences were significnat. Wound sepsis after cholecystectomy occurs mostly in patients with infected bile. Co-trimoxazole given by intravenous infusion rapidly achieves a high concentration in the palsma and is effective against most biliary pathogens.
摘要
进行了一项双盲研究，以测试单剂量复方新诺明对择期胆囊切除术后脓毒症并发症发生率的预防作用。48名患者接受复方新诺明治疗，47名患者接受安慰剂治疗。对照组中有10例（21%）发生伤口感染，而治疗组仅2例（4%）发生伤口感染，肺部并发症的发生率分别为49%（23例）和19%（9例）。这些差异具有统计学意义。胆囊切除术后伤口感染大多发生在胆汁感染的患者中。静脉输注复方新诺明可迅速在血浆中达到高浓度，且对大多数胆道病原体有效。
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