Strachan C J, Black J, Powis S J, Waterworth T A, Wise R, Wilkinson A R, Burdon D W, Severn M, Mitra B, Norcott H
Br Med J. 1977 May 14;1(6071):1254-6. doi: 10.1136/bmj.1.6071.1254.
A trial of antibiotic prophylaxis with cephazolin against postoperative wound sepsis was carried out on 201 patients undergoing routine cholecystectomy. Wound sepsis occurred in 11 out of 65 controls (16.9%), who were not given the drug; two out of 63 patients (3.2%) given a single dose preoperatively; and four out of 73 patients (5.5%) given the single preoperative dose plus a five-day course postoperatively. The difference between the controls and patients given the single preoperative dose was significant.
对201例行常规胆囊切除术的患者进行了一项使用头孢唑林预防术后伤口感染的试验。65名未使用该药物的对照组患者中有11人（16.9%）发生伤口感染；63名术前接受单剂量药物治疗的患者中有2人（3.2%）发生感染；73名术前接受单剂量药物治疗且术后接受为期五天疗程治疗的患者中有4人（5.5%）发生感染。对照组与术前接受单剂量药物治疗的患者之间的差异具有统计学意义。
