Zhang Zhongwei, Tanaka Izumi, Pan Zhen, Ernst Peter B, Kiyono Hiroshi, Kurashima Yosuke
Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA.
Eur J Immunol. 2022 Jul;52(7):1035-1046. doi: 10.1002/eji.202149532. Epub 2022 May 15.
The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and bloodstream, respectively. Growing evidence suggests that the roles of the pancreas extend to not only the secretion of digestive enzymes and hormones but also to the regulation of intestinal homeostasis and inflammation (e.g., mucosal defense to pathogens and pathobionts). Organ crosstalk between the pancreas and intestine is linked to a range of physiological, immunological, and pathological activities, such as the regulation of the gut microbiota by the pancreatic proteins and lipids, the retroaction of the gut microbiota on the pancreas, the relationship between inflammatory bowel disease, and pancreatic diseases. We herein discuss the current understanding of the pancreas-intestinal barrier axis and the control of commensal bacteria in intestinal inflammation.
胰腺包含外分泌腺，其释放对消化很重要的酶（如淀粉酶、胰蛋白酶和脂肪酶）以及胰岛，胰岛产生激素。消化酶和激素分别从胰腺分泌到十二指肠和血液中。越来越多的证据表明，胰腺的作用不仅扩展到消化酶和激素的分泌，还延伸到肠道稳态和炎症的调节（如对病原体和共生菌的黏膜防御）。胰腺和肠道之间的器官串扰与一系列生理、免疫和病理活动相关，如胰腺蛋白质和脂质对肠道微生物群的调节、肠道微生物群对胰腺的反作用、炎症性肠病与胰腺疾病之间的关系。我们在此讨论对胰腺 - 肠道屏障轴以及肠道炎症中共生菌控制的当前认识。
