Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan.
Department of Materials Engineering and Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Langmuir. 2022 May 10;38(18):5812-5819. doi: 10.1021/acs.langmuir.2c00423. Epub 2022 Apr 27.
Hydrophilic poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) shows biocompatibility because the pendant phosphorylcholine group has the same chemical structure as the hydrophilic part of phospholipids that form cell membranes. Hollow particles can be used in various fields, such as a carrier in drug delivery systems because they can encapsulate hydrophilic drugs. In this study, vinyl group-decorated silica particles with a radius of 150 nm were covered with cross-linked PMPC based on the graft-through method. The radius of PMPC-coated silica particles increased compared to that of the original silica particles. The PMPC-coated silica particles were immersed in a hydrogen fluoride aqueous solution to remove template silica particles to prepare the hollow particles. The PMPC hollow particles were characterized by dynamic light scattering, infrared spectroscopy, thermogravimetric analysis, and transmission electron microscopy observations. The thickness of the hollow particle shell can be controlled by the polymerization solvent quality. When a poor solvent for PMPC was used for the polymerization, PMPC hollow particles with thick shells can be obtained. The PMPC hollow particles can encapsulate hydrophilic guest molecules by immersing the hollow particles in a high-concentration guest molecule solution. The biocompatible PMPC hollow particles can be used in a drug carrier.
亲水性聚（2-（甲基丙烯酰氧基）乙基磷酸胆碱）（PMPC）因其侧基膦酰胆碱基团具有与细胞膜磷脂的亲水区相同的化学结构而具有生物相容性。中空粒子可以在各种领域中使用，例如药物输送系统的载体，因为它们可以包裹亲水性药物。在这项研究中，通过接枝贯穿法在半径为 150nm 的乙烯基官能化硅球上覆盖交联的 PMPC。与原始硅球相比，PMPC 包覆的硅球的半径增加了。将 PMPC 包覆的硅球浸入氢氟酸水溶液中以除去模板硅球来制备中空粒子。通过动态光散射、红外光谱、热重分析和透射电子显微镜观察对 PMPC 中空粒子进行了表征。中空粒子壳的厚度可以通过聚合溶剂的质量来控制。当使用对 PMPC 为不良溶剂的聚合溶剂时，可以得到具有厚壳的 PMPC 中空粒子。通过将中空粒子浸入高浓度客体分子溶液中，可以封装亲水性客体分子。生物相容性 PMPC 中空粒子可用作药物载体。
