Int J Oral Maxillofac Implants. 2022 Mar-Apr;37(2):373-380. doi: 10.11607/jomi.9216.
To evaluate the efficacy of autogenous particulate dentin as a bone substitute to maintain dimensional volume in human socket preservation procedures.
Particulate dentin was used in socket site preservation procedures. The extracted natural tooth was ground to particles 250 to 1,200 μm in size to fill the socket site. At 6 months, during the implant placement stage, hard tissue biopsy specimens were harvested by a 2.5-mm cylindrical trephine bur for the histologic analysis. Histomorphometry was carried out with ImageJ software to calculate direct bone to grafted dentin particles contact, newly formed bone, and particulate dentin area fractions.
Fifteen patients went through the socket preservation procedure using particulate dentin as the grafted bone substitute. De novo bone formation filled the entire grafted area. Newly formed bone was observed throughout the entire grafted area, particularly around the grafted dentin particles. The majority of particles were surrounded by direct contact with newly formed osseous tissue enriched by osteocytes. Newly formed bone ankylosed to particulate dentin and became a solid matrix preserving the ridge dimension. Histomorphometric measurements showed that the new bone formation area fraction was on average 38.4% ± 16.5%, while the residual particulate dentin showed an average of 29.9% ± 14.4%, and 31.7% ± 14.2% was captured by the connective tissue component. Particulate dentin was in direct contact with newly formed bone at an average rate of 69.1% ± 22.8%.
Particulate dentin showed complete biocompatibility and high osteoconduction. Thus, it can be used as an appropriate grafting biomaterial to maintain socket site volume dimensionally for subsequent implant placement procedures.
评估自体颗粒牙本质作为骨替代物在人牙槽窝保存术中维持体积的功效。
在牙槽窝位点保存术中使用颗粒牙本质。从提取的天然牙上磨下 250 至 1200μm 大小的颗粒来填充牙槽窝。在 6 个月时，在植入物放置阶段，通过 2.5mm 圆柱形环钻收集硬组织活检标本，用于组织学分析。使用 ImageJ 软件进行组织形态计量学分析，计算直接骨与移植牙本质颗粒的接触、新形成的骨和颗粒牙本质的面积分数。
15 名患者接受了使用颗粒牙本质作为移植骨替代物的牙槽窝保存术。新骨形成填满了整个移植区域。在整个移植区域都观察到新骨形成，特别是在移植牙本质颗粒周围。大多数颗粒被直接与富含骨细胞的新形成的骨组织接触所包围。新形成的骨与颗粒牙本质结合，并成为保持牙槽嵴尺寸的坚固基质。组织形态计量学测量显示，新骨形成面积分数平均为 38.4%±16.5%，而残留的颗粒牙本质平均为 29.9%±14.4%，结缔组织成分平均为 31.7%±14.2%。颗粒牙本质与新形成的骨的直接接触率平均为 69.1%±22.8%。
颗粒牙本质显示出完全的生物相容性和高骨引导性。因此，它可用作一种合适的移植生物材料，以维持牙槽窝的体积尺寸，为随后的植入物放置手术做准备。
