D'Souza Areetha, Marshall Liam R, Yoon Jennifer, Kulesha Alona, Edirisinghe Dona I U, Chandrasekaran Siddarth, Rathee Parth, Prabhakar Rajeev, Makhlynets Olga V
Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA.
National Biomedical Center for Advanced ESR Technology, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14583, USA.
Nano Converg. 2022 Apr 27;9(1):18. doi: 10.1186/s40580-022-00309-7.
We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.
我们合理设计了一种肽，它能组装成一种对氧化还原有响应的抗菌金属水凝胶。所得的自愈材料在生理条件下能被抗坏血酸盐迅速还原，并且在还原后水凝胶硬度呈现出显著的160倍变化。我们提供了该水凝胶的计算模型，解释了非天然氨基酸吡啶基丙氨酸中氮的位置为何会导致肽与金属离子形成的凝胶化特性有极大差异。鉴于其抗菌和流变学特性，新设计的水凝胶可用于可移除伤口敷料应用，满足临床护理中一个主要的未满足需求。
