Feng Jing, Ding Yan, Wang Zifei, Bao Chongyun, Xiao Yu
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Med-X Center for Materials, Sichuan University, Chengdu, Sichuan 610041, China.
ACS Appl Mater Interfaces. 2023 Nov 3. doi: 10.1021/acsami.3c11882.
The management of infected wound healing remains a formidable challenge primarily due to the absence of an ideal wound dressing that can not only effectively inhibit persistent bacterial infection and mitigate excessive inflammation but also possess appropriate mechanical strength, moderate adhesiveness, and favorable self-healability to maintain its protective function and facilitate easy change. In this study, we present an effective strategy for the preparation of a novel composite hydrogel under mild conditions, without the need for additives. This is achieved by incorporating resveratrol (RSV)-loaded alkali lignin nanoparticles (ARNPs) into an advanced polyacrylamide-based hydrogel matrix. The utilization of ARNPs facilitated the sustained release of RSV, thereby enhancing its bioavailability. The polymerization of acrylamide was gently triggered by free radicals generated through a novel dual self-redox mechanism involving silver ions (Ag), catechols, and ammonium persulfate in neutral and at room temperature, without the requirement of cross-linkers. The dual self-redox reactions played a dominant role in facilitating the gelation process and imparting the desired properties to the resulting hydrogels. The obtained product exhibited exceptional antibacterial properties, favorable anti-inflammatory activity, superior tensile strength, moderate adhesiveness, and reliable self-healability, thereby accelerating the closure of infected wounds. Collectively, this study synergistically integrated RSV-sustained release nanoparticles and a specially designed multifunctional hydrogel into a single system in a conveniently manipulable manner. This composite wound dressing material holds promise for promoting the healing of infected wounds and has potential applications in other complex wound treatments.
感染伤口愈合的管理仍然是一项艰巨的挑战，主要原因是缺乏一种理想的伤口敷料，它不仅能有效抑制持续性细菌感染并减轻过度炎症，还具有适当的机械强度、适度的粘附性和良好的自愈性，以维持其保护功能并便于更换。在本研究中，我们提出了一种在温和条件下制备新型复合水凝胶的有效策略，无需添加剂。这是通过将负载白藜芦醇（RSV）的碱木质素纳米颗粒（ARNPs）掺入先进的聚丙烯酰胺基水凝胶基质中来实现的。ARNPs的利用促进了RSV的持续释放，从而提高了其生物利用度。丙烯酰胺的聚合是由一种新型双自氧化还原机制产生的自由基在中性和室温下温和引发的，该机制涉及银离子（Ag）、儿茶酚和过硫酸铵，无需交联剂。双自氧化还原反应在促进凝胶化过程和赋予所得水凝胶所需性能方面起主导作用。所得产品表现出优异的抗菌性能、良好的抗炎活性、出色的拉伸强度、适度的粘附性和可靠的自愈性，从而加速感染伤口的愈合。总的来说，本研究以方便操作的方式将RSV持续释放纳米颗粒和特别设计的多功能水凝胶协同整合到一个单一系统中。这种复合伤口敷料材料有望促进感染伤口的愈合，并在其他复杂伤口治疗中具有潜在应用。
