miRNA-145 单核苷酸多态性与腹主动脉瘤的相关性研究。
Association of miRNA-145 Single Nucleotide Polymorphisms in Abdominal Aortic Aneurysms.
机构信息
First Department of Surgery, Vascular Unit, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
Department of Basic Medical Science, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
In Vivo. 2022 May-Jun;36(3):1120-1125. doi: 10.21873/invivo.12810.
BACKGROUND/AIM: MicroRNAs (miRNAs) are non-coding RNA molecules that exert post-transcriptional gene expression regulation in response to cellular or environmental changes. Genetic variation affects their synthesis and cellular actions, and single nucleotide polymorphisms (SNPs) are one example of genetic variants studied in relation to various diseases. Literature indicates that the differentially expressed miRNA-145 in patients' serum is an essential biomarker for abdominal aortic aneurysm (AAA). However, the correlation between specific miR-145 genetic polymorphisms with AAA susceptibility is inadequately studied.
MATERIALS AND METHODS
Eighty-seven AAA patients and 122 healthy controls were recruited. Peripheral blood samples were genotyped for miRNA-145 SNPs; rs55945735, rs73798217 and rs353291.
RESULTS
The GG genotype of the rs55945735 polymorphism (p=0.047) and the AG genotype of the rs353291 polymorphism (p=0.036) were overrepresented in AAA patients compared to healthy individuals, revealing an association with susceptibility to AAA development.
CONCLUSION
SNPs rs55945735 and rs353291 are associated with AAA susceptibility.
背景/目的：微小 RNA（miRNAs）是一类非编码 RNA 分子，能够针对细胞或环境变化，发挥转录后基因表达调控作用。遗传变异会影响 miRNA 的合成和细胞作用，而单核苷酸多态性（SNP）是与各种疾病相关的遗传变异之一。文献表明，患者血清中差异表达的 miRNA-145 是腹主动脉瘤（AAA）的重要生物标志物。然而，特定 miR-145 遗传多态性与 AAA 易感性的相关性尚未得到充分研究。
材料和方法
招募了 87 名 AAA 患者和 122 名健康对照者。对 miRNA-145 SNP（rs55945735、rs73798217 和 rs353291）进行外周血样本的基因分型。
结果
与健康个体相比，rs55945735 多态性的 GG 基因型（p=0.047）和 rs353291 多态性的 AG 基因型（p=0.036）在 AAA 患者中更为常见，表明其与 AAA 发病易感性相关。
结论
SNP rs55945735 和 rs353291 与 AAA 易感性相关。
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