Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Department of Medicine, Columbia University, New York, NY, USA.
Nat Biomed Eng. 2022 Apr;6(4):327-338. doi: 10.1038/s41551-022-00885-3. Epub 2022 Apr 27.
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease modelling and drug development. In this Perspective, we reflect on the most notable advances in cardiac tissue engineering from the past two decades by analysing pivotal studies and critically examining the most consequential developments. This retrospective analysis led us to identify key milestones and to outline a set of opportunities, along with their associated challenges, for the further advancement of engineered human cardiac tissues.
工程化人心肌组织促进了再生医学、疾病建模和药物开发的进展。在本观点文章中，我们通过分析关键研究并批判性地检查最重要的进展，反思过去二十年中在心脏组织工程方面最显著的进展。这种回顾性分析使我们能够确定关键的里程碑，并概述一系列机会及其相关挑战，以进一步推进工程化人心肌组织的发展。
