Department of Biomedical Engineering, Columbia University, New York, NY.
Department of Biomedical Engineering, Columbia University, New York, NY; Department of Medicine, Columbia University, New York, NY.
Cell Stem Cell. 2021 Jun 3;28(6):993-1015. doi: 10.1016/j.stem.2021.05.008.
Tissue engineering has markedly matured since its early beginnings in the 1980s. In addition to the original goal to regenerate damaged organs, the field has started to explore modeling of human physiology "in a dish." Induced pluripotent stem cell (iPSC) technologies now enable studies of organ regeneration and disease modeling in a patient-specific context. We discuss the potential of "organ-on-a-chip" systems to study regenerative therapies with focus on three distinct organ systems: cardiac, respiratory, and hematopoietic. We propose that the combinatorial studies of human tissues at these two scales would help realize the translational potential of tissue engineering.
组织工程自 20 世纪 80 年代初起步以来，已经取得了显著的成熟。除了最初的再生受损器官的目标外，该领域已经开始探索在“培养皿”中模拟人体生理学。诱导多能干细胞 (iPSC) 技术现在能够在特定于患者的背景下研究器官再生和疾病建模。我们讨论了“芯片上器官”系统在再生治疗研究中的潜力，重点关注三个不同的器官系统：心脏、呼吸和造血。我们提出，在这两个尺度上对人体组织进行组合研究将有助于实现组织工程的转化潜力。
