Department of Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan.
Department of Gastrointestinal Surgery, Toho University Medical Center Omori Hospital, Tokyo, Japan.
Surg Today. 2022 Nov;52(11):1551-1559. doi: 10.1007/s00595-022-02505-8. Epub 2022 Apr 27.
We evaluated the clinicopathological and prognostic significance of preoperative serum creatine kinase (CK) levels in gastric cancer.
The subjects of this retrospective study were 942 patients who underwent surgery without preoperative chemotherapy for gastric cancer (643 men and 299 women), excluding Stage IV gastric cancer, between January, 2001 and December, 2020. We set the cutoff values for CK according to gender, as 64 U/L for men and 57 U/L for women, and evaluated the clinicopathological, prognostic, and gender significance of low CK levels by multivariate analysis.
Tumor depth was significantly associated with low serum CK levels (p < 0.001). The low CK group showed significantly worse overall survival than the high CK group (p = 0.01). The prognostic impact of low CK levels was evident only in men (p = 0.009). In women, low CK levels were not an independent risk factor for poor prognosis (p = 0.33). These prognostic impacts of low CK levels on overall survival and recurrence-free survival were similar.
Low preoperative CK levels in men with gastric cancer were predictive of poor survival. These prognostic impacts of low CK levels were not evident in women.
我们评估了术前血清肌酸激酶（CK）水平在胃癌中的临床病理和预后意义。
本回顾性研究的对象为 2001 年 1 月至 2020 年 12 月期间，942 例未经术前化疗而行手术治疗的胃癌患者（男性 643 例，女性 299 例），排除 IV 期胃癌。我们根据性别设定 CK 的截断值，男性为 64 U/L，女性为 57 U/L，并通过多变量分析评估低 CK 水平的临床病理、预后和性别意义。
肿瘤深度与低血清 CK 水平显著相关（p<0.001）。低 CK 组的总生存率明显低于高 CK 组（p=0.01）。低 CK 水平对预后的影响仅在男性中显著（p=0.009）。在女性中，低 CK 水平不是预后不良的独立危险因素（p=0.33）。低 CK 水平对总生存和无复发生存的预后影响相似。
男性胃癌患者术前低 CK 水平预示着生存不良。这些低 CK 水平的预后影响在女性中并不明显。
